Chapter title |
Cancer and Zebrafish
|
---|---|
Chapter number | 3 |
Book title |
Cancer and Zebrafish
|
Published in |
Advances in experimental medicine and biology, May 2016
|
DOI | 10.1007/978-3-319-30654-4_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-930652-0, 978-3-31-930654-4
|
Authors |
Parant, John M, Yeh, Jing-Ruey Joanna, John M. Parant, Jing-Ruey Joanna Yeh, Parant, John M. |
Editors |
David M. Langenau |
Abstract |
Animal models of tumor initiation and tumor progression are essential components toward understanding cancer and designing/validating future therapies. Zebrafish is a powerful model for studying tumorigenesis and has been successfully exploited in drug discovery. According to the zebrafish reference genome, 82 % of disease-associated genes in the Online Mendelian Inheritance in Man (OMIM) database have clear zebrafish orthologues. Using a variety of large-scale random mutagenesis methods developed to date, zebrafish can provide a unique opportunity to identify gene mutations that may be associated with cancer predisposition. On the other hand, newer technologies enabling targeted mutagenesis can facilitate reverse cancer genetic studies and open the door for complex genetic analysis of tumorigenesis. In this chapter, we will describe the various technologies for conducting genome editing in zebrafish with special emphasis on the approaches to inactivate genes. |
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Unknown | 2 | 100% |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 22 | 100% |
Demographic breakdown
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Researcher | 4 | 18% |
Student > Master | 3 | 14% |
Other | 2 | 9% |
Professor | 2 | 9% |
Student > Ph. D. Student | 2 | 9% |
Other | 3 | 14% |
Unknown | 6 | 27% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 5 | 23% |
Agricultural and Biological Sciences | 4 | 18% |
Social Sciences | 2 | 9% |
Medicine and Dentistry | 2 | 9% |
Business, Management and Accounting | 1 | 5% |
Other | 2 | 9% |
Unknown | 6 | 27% |