Chapter title |
Artificial Antigen-Presenting Cells for Immunotherapies
|
---|---|
Chapter number | 21 |
Book title |
Cancer Nanotechnology
|
Published in |
Methods in molecular biology, February 2017
|
DOI | 10.1007/978-1-4939-6646-2_21 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6644-8, 978-1-4939-6646-2
|
Authors |
Alyssa L. Siefert, Tarek M. Fahmy, Dongin Kim, Siefert, Alyssa L., Fahmy, Tarek M., Kim, Dongin |
Editors |
Reema Zeineldin |
Abstract |
Artificial antigen-presenting cells (aAPCs) overcome many of the limitations of biologically based adoptive immunotherapy protocols. While these acellular systems can be designed with a variety of parameters, including material type, diameter, and proliferative signals for T cells, we outline methods to formulate and characterize a comprehensive polymeric microparticle aAPC platform. These aAPCs, which can be reproducibly fabricated in large quantities, efficiently stimulate antigen-specific T cell activation and proliferation by both paracrine cytokine signals and engagement of T cell surface proteins. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 43% |
Student > Ph. D. Student | 2 | 29% |
Student > Doctoral Student | 1 | 14% |
Professor | 1 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 14% |
Biochemistry, Genetics and Molecular Biology | 1 | 14% |
Agricultural and Biological Sciences | 1 | 14% |
Immunology and Microbiology | 1 | 14% |
Medicine and Dentistry | 1 | 14% |
Other | 2 | 29% |