| Chapter title |
Exploiting Uptake of Nanoparticles by Phagocytes for Cancer Treatment
|
|---|---|
| Chapter number | 22 |
| Book title |
Cancer Nanotechnology
|
| Published in |
Methods in molecular biology, February 2017
|
| DOI | 10.1007/978-1-4939-6646-2_22 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6644-8, 978-1-4939-6646-2
|
| Authors |
Mee Rie Sheen, Steven Fiering Ph.D., Steven Fiering |
| Editors |
Reema Zeineldin |
| Abstract |
Many cancers including ovarian, pancreatic, colon, liver, and stomach cancers are largely confined to the peritoneal cavity. Peritoneal tumors are directly accessible by intraperitoneal injections. Previously we demonstrated that intraperitoneal injection of nanoparticles and subsequent ingestion by tumor-associated phagocytes can be used to either directly impact tumors or stimulate antitumor immune responses. Here we outline methods to specifically utilize iron oxide nanoparticles with the ID8-Defb29/Vegf-A murine ovarian cancer model and discuss the tendency of phagocytes to ingest nanoparticles and the potential of phagocytes to carry nanoparticles to tumors resulting in direct killing of tumor cells or stimulate antitumor immune responses in peritoneal cancers. This basic approach can be modified as needed for different types of tumors and nanoparticles. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 2 | 20% |
| Student > Ph. D. Student | 2 | 20% |
| Student > Bachelor | 2 | 20% |
| Other | 1 | 10% |
| Unknown | 3 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 30% |
| Immunology and Microbiology | 2 | 20% |
| Agricultural and Biological Sciences | 1 | 10% |
| Unknown | 4 | 40% |