Chapter title |
Aquaporins in Nervous System
|
---|---|
Chapter number | 5 |
Book title |
Aquaporins
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-94-024-1057-0_5 |
Pubmed ID | |
Book ISBNs |
978-9-40-241055-6, 978-9-40-241057-0
|
Authors |
Mengmeng Xu Ph.D., Ming Xiao M.D., Ph.D., Shao Li M.D., Ph.D., Baoxue Yang M.D., Ph.D., Mengmeng Xu, Ming Xiao, Shao Li, Baoxue Yang |
Editors |
Baoxue Yang |
Abstract |
Aquaporins (AQPs ) mediate water flux between the four distinct water compartments in the central nervous system (CNS). In the present chapter, we mainly focus on the expression and function of the 9 AQPs expressed in the CNS, which include five members of aquaporin subfamily: AQP1, AQP4, AQP5, AQP6, and AQP8; three members of aquaglyceroporin subfamily: AQP3, AQP7, and AQP9; and one member of superaquaporin subfamily: AQP11. In addition, AQP1, AQP2 and AQP4 expressed in the peripheral nervous system (PNS) are also reviewed. AQP4, the predominant water channel in the CNS, is involved both in the astrocyte swelling of cytotoxic edema and the resolution of vasogenic edema, and is of pivotal importance in the pathology of brain disorders such as neuromyelitis optica , brain tumors and Alzheimer's disease. Other AQPs are also involved in a variety of important physiological and pathological process in the brain. It has been suggested that AQPs could represent an important target in treatment of brain disorders like cerebral edema. Future investigations are necessary to elucidate the pathological significance of AQPs in the CNS. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 27% |
Other | 5 | 14% |
Student > Ph. D. Student | 4 | 11% |
Student > Master | 4 | 11% |
Researcher | 3 | 8% |
Other | 4 | 11% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 24% |
Neuroscience | 8 | 22% |
Agricultural and Biological Sciences | 4 | 11% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Computer Science | 1 | 3% |
Other | 2 | 5% |
Unknown | 10 | 27% |