Title |
High-throughput microarray technology in diagnostics of enterobacteria based on genome-wide probe selection and regression analysis
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Published in |
BMC Genomics, October 2010
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DOI | 10.1186/1471-2164-11-591 |
Pubmed ID | |
Authors |
Torben Friedrich, Sven Rahmann, Wilfried Weigel, Wolfgang Rabsch, Angelika Fruth, Eliora Ron, Florian Gunzer, Thomas Dandekar, Jörg Hacker, Tobias Müller, Ulrich Dobrindt |
Abstract |
The Enterobacteriaceae comprise a large number of clinically relevant species with several individual subspecies. Overlapping virulence-associated gene pools and the high overall genome plasticity often interferes with correct enterobacterial strain typing and risk assessment. Array technology offers a fast, reproducible and standardisable means for bacterial typing and thus provides many advantages for bacterial diagnostics, risk assessment and surveillance. The development of highly discriminative broad-range microbial diagnostic microarrays remains a challenge, because of marked genome plasticity of many bacterial pathogens. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Estonia | 1 | 2% |
Germany | 1 | 2% |
Unknown | 56 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 24% |
Student > Ph. D. Student | 9 | 16% |
Student > Doctoral Student | 4 | 7% |
Unspecified | 4 | 7% |
Student > Master | 4 | 7% |
Other | 11 | 19% |
Unknown | 12 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 24% |
Medicine and Dentistry | 5 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Computer Science | 4 | 7% |
Unspecified | 4 | 7% |
Other | 13 | 22% |
Unknown | 14 | 24% |