Chapter title |
Transcriptional and Post-transcriptional Regulation of Drosophila Germline Stem Cells and Their Differentiating Progeny.
|
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Chapter number | 4 |
Book title |
Transcriptional and Translational Regulation of Stem Cells
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Published in |
Advances in experimental medicine and biology, January 2013
|
DOI | 10.1007/978-94-007-6621-1_4 |
Pubmed ID | |
Book ISBNs |
978-9-40-076620-4, 978-9-40-076621-1
|
Authors |
Helen White-Cooper, Simona Caporilli |
Abstract |
In this chapter we will concentrate on the transcriptional and translational regulations that govern the development and differentiation of male germline cells. Our focus will be on the processes that occur during differentiation, that distinguish the differentiating population of cells from their stem cell parents. We discuss how these defining features are established as cells transit from a stem cell character to that of a fully committed differentiating cell. The focus will be on how GSCs differentiate, via spermatogonia, to spermatocytes. We will achieve this by first describing the transcriptional activity in the differentiating spermatocytes, cataloguing the known transcriptional regulators in these cells and then investigating how the transcription programme is set up by processes in the progentior cells. This process is particularly interesting to study from a stem cell perspective as the male GSCs are unipotent, so lineage decisions in differentiating progeny of stem cells, which occurs in many other stem cell systems, do not impinge on the behaviour of these cells. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 1 | 33% |
Researcher | 1 | 33% |
Unknown | 1 | 33% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 67% |
Unknown | 1 | 33% |