Chapter title |
Stem cells in the Drosophila digestive system.
|
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Chapter number | 5 |
Book title |
Transcriptional and Translational Regulation of Stem Cells
|
Published in |
Advances in experimental medicine and biology, January 2013
|
DOI | 10.1007/978-94-007-6621-1_5 |
Pubmed ID | |
Book ISBNs |
978-9-40-076620-4, 978-9-40-076621-1
|
Authors |
Zeng X, Chauhan C, Hou SX, Xiankun Zeng, Chhavi Chauhan, Steven X. Hou |
Abstract |
Adult stem cells maintain tissue homeostasis by continuously replenishing damaged, aged and dead cells in any organism. Five types of region and organ-specific multipotent adult stem cells have been identified in the Drosophila digestive system: intestinal stem cells (ISCs) in the posterior midgut; hindgut intestinal stem cells (HISCs) at the midgut/hindgut junction; renal and nephric stem cells (RNSCs) in the Malpighian Tubules; type I gastric stem cells (GaSCs) at foregut/midgut junction; and type II gastric stem cells (GSSCs) at the middle of the midgut. Despite the fact that each type of stem cell is unique to a particular organ, they share common molecular markers and some regulatory signaling pathways. Due to the simpler tissue structure, ease of performing genetic analysis, and availability of abundant mutants, Drosophila serves as an elegant and powerful model system to study complex stem cell biology. The recent discoveries, particularly in the Drosophila ISC system, have greatly advanced our understanding of stem cell self-renewal, differentiation, and the role of stem cells play in tissue homeostasis/regeneration and adaptive tissue growth. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 2 | 17% |
Student > Bachelor | 1 | 8% |
Researcher | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Unknown | 7 | 58% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 33% |
Environmental Science | 1 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Unknown | 6 | 50% |