Chapter title |
Small RNA-Guided Transcriptional Gene Activation (RNAa) in Mammalian Cells
|
---|---|
Chapter number | 1 |
Book title |
Advances in Experimental Medicine and Biology
|
Published in |
Advances in experimental medicine and biology, June 2017
|
DOI | 10.1007/978-981-10-4310-9_1 |
Pubmed ID | |
Book ISBNs |
978-9-81-104309-3, 978-9-81-104310-9
|
Authors |
Li, Long-Cheng, Long-Cheng Li |
Editors |
Long-Cheng Li |
Abstract |
Small RNA partnering with Argonaute (Ago) proteins plays important roles in diverse biological processes mainly by suppressing the expression of cognate target sequences. Mounting evidence reveals that the small RNA-Ago pathway can also positively regulate gene expression, a phenomenon termed as RNA activation (RNAa), which is evolutionarily conserved from Caenorhabditis elegans to human. In this chapter, I provide a general overview of mammalian RNAa phenomena and their basic characteristics and discuss recent advances toward understanding the nature of the molecular machinery responsible for RNAa and the development of RNAa-based research tools and therapeutics. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 18% |
Student > Bachelor | 2 | 12% |
Student > Postgraduate | 2 | 12% |
Student > Master | 1 | 6% |
Student > Doctoral Student | 1 | 6% |
Other | 2 | 12% |
Unknown | 6 | 35% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 41% |
Agricultural and Biological Sciences | 3 | 18% |
Medicine and Dentistry | 1 | 6% |
Unknown | 6 | 35% |