| Chapter title |
Endogenous miRNAa: miRNA-Mediated Gene Upregulation
|
|---|---|
| Chapter number | 5 |
| Book title |
RNA Activation
|
| Published in |
Advances in experimental medicine and biology, June 2017
|
| DOI | 10.1007/978-981-10-4310-9_5 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-104309-3, 978-9-81-104310-9
|
| Authors |
Vera Huang |
| Editors |
Long-Cheng Li |
| Abstract |
The phenomenon of RNA activation (RNAa) was initially discovered by Li and colleagues about a decade ago. Subsequently, gene activation by exogenously expressed small activating RNA has been demonstrated in different cellular contexts by a number of laboratories. Conceivably, endogenously expressed microRNAs may also utilize RNA activation as a cellular mechanism for gene regulation, which may be dysregulated in disease states such as cancer. RNA activation can be applied to gain-of-function studies and holds great promise for disease intervention. This chapter will discuss examples of promoter-targeting microRNAs discovered in recent years and their pathophysiological relevance. I will also briefly touch upon other novel classes of microRNAs with positive gene regulatory roles, including TATA-box-activating microRNAs and enhancer-associated microRNAs. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 2 | 6% |
| Student > Doctoral Student | 1 | 3% |
| Researcher | 1 | 3% |
| Unknown | 28 | 88% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Agricultural and Biological Sciences | 1 | 3% |
| Unknown | 28 | 88% |