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Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine

Overview of attention for article published in Journal of Venomous Animals and Toxins including Tropical Diseases, May 2017
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1 Wikipedia page

Citations

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Title
Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine
Published in
Journal of Venomous Animals and Toxins including Tropical Diseases, May 2017
DOI 10.1186/s40409-017-0118-7
Pubmed ID
Authors

Ricardo Teixeira-Araújo, Patrícia Castanheira, Leonora Brazil-Más, Francisco Pontes, Moema Leitão de Araújo, Maria Lucia Machado Alves, Russolina Benedeta Zingali, Carlos Correa-Netto

Abstract

Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable immunization protocol and proper venom mixtures. In Brazil, antivenom against South American rattlesnake (Crotalus durissus terrificus) bites is produced by public institutions based on the guidelines defined by the regulatory agency of the Brazilian Ministry of Health, ANVISA. However, each institution uses its own mixture of rattlesnake venom antigens. Previous works have shown that crotamine, a toxin found in Crolatus durissus venom, shows marked individual and populational variation. In addition, serum produced from crotamine-negative venoms fails to recognize this molecule. In this work, we used an antivenomics approach to assess the cross-reactivity of crotalic antivenom manufactured by IVB towards crotamine-negative venom and a mixture of crotamine-negative/crotamine-positive venoms. We show that the venom mixture containing 20% crotamine and 57% crotoxin produced a strong immunogenic response in horses. Antivenom raised against this venom mixture reacted with most venom components including crotamine and crotoxin, in contrast to the antivenom raised against crotamine-negative venom. These results indicate that venomic databases and antivenomics analysis provide a useful approach for choosing the better venom mixture for antibody production and for the subsequent screening of antivenom cross-reactivity with relevant snake venom components.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 15 26%
Student > Master 5 9%
Professor 4 7%
Student > Doctoral Student 4 7%
Student > Ph. D. Student 4 7%
Other 8 14%
Unknown 17 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 18%
Agricultural and Biological Sciences 9 16%
Pharmacology, Toxicology and Pharmaceutical Science 6 11%
Immunology and Microbiology 3 5%
Medicine and Dentistry 2 4%
Other 6 11%
Unknown 21 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2021.
All research outputs
#7,755,906
of 26,362,847 outputs
Outputs from Journal of Venomous Animals and Toxins including Tropical Diseases
#144
of 545 outputs
Outputs of similar age
#111,249
of 329,340 outputs
Outputs of similar age from Journal of Venomous Animals and Toxins including Tropical Diseases
#2
of 10 outputs
Altmetric has tracked 26,362,847 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 545 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,340 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.