Title |
Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
|
---|---|
Published in |
International Journal of Nanomedicine, January 2014
|
DOI | 10.2147/ijn.s53079 |
Pubmed ID | |
Authors |
Samer Hasan Hussein-Al-Ali, Mohamed Ezzat El Zowalaty, Mohd Zobir Hussein, Maznah Ismail, Thomas J Webster |
Abstract |
This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Streptomycin was incorporated into the nanoparticles to form a streptomycin-coated chitosan-magnetic nanoparticle (Strep-CS-MNP) nanocomposite. The release profiles showed an initially fast release, which became slower as time progressed. The percentage of drug released after 350 minutes was around 100%, and the best fit mathematical model for drug release was the pseudo-second order model. The Strep-CS-MNP nanocomposite showed enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus. This study forms a significant basis for further investigation of the Strep-CS-MNP nanocomposite in the treatment of various bacterial infections. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 113 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 22% |
Student > Master | 19 | 17% |
Researcher | 10 | 9% |
Student > Bachelor | 6 | 5% |
Other | 6 | 5% |
Other | 20 | 17% |
Unknown | 29 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 15 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 10% |
Biochemistry, Genetics and Molecular Biology | 11 | 10% |
Engineering | 7 | 6% |
Materials Science | 7 | 6% |
Other | 27 | 23% |
Unknown | 36 | 31% |