Chapter title |
Glycan Markers as Potential Immunological Targets in Circulating Tumor Cells
|
---|---|
Chapter number | 15 |
Book title |
Isolation and Molecular Characterization of Circulating Tumor Cells
|
Published in |
Advances in experimental medicine and biology, May 2017
|
DOI | 10.1007/978-3-319-55947-6_15 |
Pubmed ID | |
Book ISBNs |
978-3-31-955946-9, 978-3-31-955947-6
|
Authors |
Wang, Denong, Wu, Lisa, Liu, Xiaohe, Denong Wang, Lisa Wu, Xiaohe Liu |
Abstract |
We present here an experimental approach for exploring a new class of tumor biomarkers that are overexpressed by circulating tumor cells (CTCs) and are likely targetable in immunotherapy against tumor metastasis. Using carbohydrate microarrays, anti-tumor monoclonal antibodies (mAbs) were scanned against a large panel of carbohydrate antigens to identify potential tumor glycan markers. Subsequently, flow cytometry and fiber-optic array scanning technology (FAST) were applied to determine whether the identified targets are tumor-specific cell-surface markers and are, therefore, likely suitable for targeted immunotherapy. Finally, the tumor glycan-specific antibodies identified were validated using cancer patients' blood samples for their performance in CTC-detection and immunotyping analysis. In this article, identifying breast CTC-specific glycan markers and targeting mAbs serve as examples to illustrate this tumor biomarker discovery strategy. |
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