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Hippocampal BDNF in physiological conditions and social isolation

Overview of attention for article published in Reviews in the neurosciences, July 2017
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Hippocampal BDNF in physiological conditions and social isolation
Published in
Reviews in the neurosciences, July 2017
DOI 10.1515/revneuro-2016-0072
Pubmed ID

Ivan Zaletel, Dragana Filipović, Nela Puškaš


Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. Given that depression in humans has been linked with social stress, the chronic social stress paradigms for modeling psychiatric disorders in animals have thus been developed. Chronic social isolation in animal models generally causes changes in hypothalamic-pituitary-adrenal axis functioning, associated with anxiety- and depressive-like behaviors. Also, this chronic stress causes downregulation of BDNF protein and mRNA in the hippocampus, a stress-sensitive brain region closely related to the pathophysiology of depression. In this review, we discuss the current knowledge regarding the structure, function, intracellular signaling, inter-individual differences and epigenetic regulation of BDNF in both physiological conditions and depression and changes in corticosterone levels, as a marker of stress response. Since BDNF levels are age dependent in humans and rodents, this review will also highlight the effects of adolescent and adult chronic social isolation models of both genders on the BDNF expression.

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Mendeley readers

The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 122 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 20%
Student > Bachelor 19 16%
Student > Master 17 14%
Researcher 10 8%
Student > Doctoral Student 6 5%
Other 18 15%
Unknown 28 23%
Readers by discipline Count As %
Neuroscience 28 23%
Medicine and Dentistry 12 10%
Biochemistry, Genetics and Molecular Biology 8 7%
Nursing and Health Professions 7 6%
Psychology 7 6%
Other 24 20%
Unknown 36 30%