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Hippocampal BDNF in physiological conditions and social isolation

Overview of attention for article published in Reviews in the Neurosciences, April 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
68 Dimensions

Readers on

mendeley
153 Mendeley
Summary Twitter Dimensions citations
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Title
Hippocampal BDNF in physiological conditions and social isolation
Published in
Reviews in the Neurosciences, April 2017
DOI 10.1515/revneuro-2016-0072
Pubmed ID
28593903
Authors

Ivan Zaletel, Dragana Filipović, Nela Puškaš

Abstract

Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. Given that depression in humans has been linked with social stress, the chronic social stress paradigms for modeling psychiatric disorders in animals have thus been developed. Chronic social isolation in animal models generally causes changes in hypothalamic-pituitary-adrenal axis functioning, associated with anxiety- and depressive-like behaviors. Also, this chronic stress causes downregulation of BDNF protein and mRNA in the hippocampus, a stress-sensitive brain region closely related to the pathophysiology of depression. In this review, we discuss the current knowledge regarding the structure, function, intracellular signaling, inter-individual differences and epigenetic regulation of BDNF in both physiological conditions and depression and changes in corticosterone levels, as a marker of stress response. Since BDNF levels are age dependent in humans and rodents, this review will also highlight the effects of adolescent and adult chronic social isolation models of both genders on the BDNF expression.

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Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 153 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 16%
Student > Master 23 15%
Student > Bachelor 20 13%
Researcher 15 10%
Student > Doctoral Student 9 6%
Other 23 15%
Unknown 39 25%
Readers by discipline Count As %
Neuroscience 33 22%
Medicine and Dentistry 15 10%
Biochemistry, Genetics and Molecular Biology 10 7%
Psychology 7 5%
Pharmacology, Toxicology and Pharmaceutical Science 7 5%
Other 29 19%
Unknown 52 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2022.
All research outputs
#7,605,103
of 23,438,856 outputs
Outputs from Reviews in the Neurosciences
#192
of 451 outputs
Outputs of similar age
#120,039
of 310,933 outputs
Outputs of similar age from Reviews in the Neurosciences
#1
of 1 outputs
Altmetric has tracked 23,438,856 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 451 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,933 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them

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