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Mendeley readers
Attention Score in Context
| Title |
Hippocampal BDNF in physiological conditions and social isolation
|
|---|---|
| Published in |
Reviews in the Neurosciences, April 2017
|
| DOI | 10.1515/revneuro-2016-0072 |
| Pubmed ID | |
| Authors |
Ivan Zaletel, Dragana Filipović, Nela Puškaš |
| Abstract |
Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. Given that depression in humans has been linked with social stress, the chronic social stress paradigms for modeling psychiatric disorders in animals have thus been developed. Chronic social isolation in animal models generally causes changes in hypothalamic-pituitary-adrenal axis functioning, associated with anxiety- and depressive-like behaviors. Also, this chronic stress causes downregulation of BDNF protein and mRNA in the hippocampus, a stress-sensitive brain region closely related to the pathophysiology of depression. In this review, we discuss the current knowledge regarding the structure, function, intracellular signaling, inter-individual differences and epigenetic regulation of BDNF in both physiological conditions and depression and changes in corticosterone levels, as a marker of stress response. Since BDNF levels are age dependent in humans and rodents, this review will also highlight the effects of adolescent and adult chronic social isolation models of both genders on the BDNF expression. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 157 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 15% |
| Student > Bachelor | 21 | 13% |
| Student > Master | 20 | 13% |
| Researcher | 15 | 10% |
| Student > Doctoral Student | 9 | 6% |
| Other | 21 | 13% |
| Unknown | 47 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 31 | 20% |
| Medicine and Dentistry | 16 | 10% |
| Biochemistry, Genetics and Molecular Biology | 10 | 6% |
| Psychology | 8 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Other | 25 | 16% |
| Unknown | 60 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2022.
All research outputs
#8,428,959
of 25,382,440 outputs
Outputs from Reviews in the Neurosciences
#214
of 481 outputs
Outputs of similar age
#126,169
of 324,698 outputs
Outputs of similar age from Reviews in the Neurosciences
#7
of 14 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 481 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,698 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.