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Peptide Synthesis and Applications

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Cover of 'Peptide Synthesis and Applications'

Table of Contents

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    Book Overview
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    Chapter 1 Solid-Phase Peptide Synthesis: An Introduction
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    Chapter 2 Linkers, Resins, and General Procedures for Solid-Phase Peptide Synthesis
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    Chapter 3 Peptide Release, Side-Chain Deprotection, Work-Up, and Isolation
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    Chapter 4 Synthesis of Peptides Using Tert -Butyloxycarbonyl (Boc) as the α-Amino Protection Group
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    Chapter 5 Sequential Formation of Regioselective Disulfide Bonds in Synthetic Peptides with Multiple Disulfide Bonds
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    Chapter 6 Synthesis of Cyclic Disulfide-Rich Peptides
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    Chapter 7 Preparation of C-terminally Modified Chemokines by Expressed Protein Ligation.
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    Chapter 8 Synthesis of C-Terminal Peptide Thioesters Using Fmoc-Based Solid-Phase Peptide Chemistry
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    Chapter 9 Backbone Amide Linker Strategy: Protocols for the Synthesis of C-Terminal Peptide Aldehydes
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    Chapter 10 Synthesis of N-Methylated Peptides: On-Resin Methylation and Microwave-Assisted Couplings
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    Chapter 11 Synthesis of Antimicrobial Peptoids
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    Chapter 12 Synthesis of Lipidated Peptides
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    Chapter 13 Solid-Phase Synthesis of Phosphopeptides
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    Chapter 14 Synthesis of O -Glycopeptides and Construction of Glycopeptide Microarrays
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    Chapter 15 Instruments for Automated Peptide Synthesis
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    Chapter 16 Microwave-Assisted Solid-Phase Peptide Synthesis Using the Biotage Syro Wave ™
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    Chapter 17 Microwave-Assisted Solid-Phase Peptide Synthesis Based on the Fmoc Protecting Group Strategy (CEM)
Attention for Chapter 5: Sequential Formation of Regioselective Disulfide Bonds in Synthetic Peptides with Multiple Disulfide Bonds
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Chapter title
Sequential Formation of Regioselective Disulfide Bonds in Synthetic Peptides with Multiple Disulfide Bonds
Chapter number 5
Book title
Peptide Synthesis and Applications
Published in
Methods in molecular biology, January 2013
DOI 10.1007/978-1-62703-544-6_5
Pubmed ID
Book ISBNs
978-1-62703-543-9, 978-1-62703-544-6
Authors

Fazel Shabanpoor, Mohammed Akhter Hossain, Feng Lin, John D. Wade, Shabanpoor, Fazel, Hossain, Mohammed Akhter, Lin, Feng, Wade, John D.

Abstract

Numerous methods have been developed for the formation of disulfide bonds in recombinant DNA-derived and chemically synthesized peptides and proteins, but only a few have found widespread acceptance. The choice of method(s) for formation of disulfide in synthetic peptides and proteins needs to be tailored for each individual polypeptide in such a way so that the reaction conditions are selective, efficient, and safe and give the maximum yield. Here we describe the sequential formation of three disulfide bonds regioselectively which has been optimized for the synthesis of two-chained, heterodimeric polypeptide members of the insulin-relaxin superfamily.

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Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 20%
Student > Ph. D. Student 1 20%
Researcher 1 20%
Lecturer 1 20%
Unknown 1 20%
Readers by discipline Count As %
Chemistry 2 40%
Pharmacology, Toxicology and Pharmaceutical Science 1 20%
Unknown 2 40%