Title |
Interferons-beta versus glatiramer acetate for relapsing-remitting multiple sclerosis
|
---|---|
Published in |
Cochrane database of systematic reviews, July 2014
|
DOI | 10.1002/14651858.cd009333.pub2 |
Pubmed ID | |
Authors |
La Mantia L, Di Pietrantonj C, Rovaris M, Rigon G, Frau S, Berardo F, Gandini A, Longobardi A, Weinstock-Guttman B, Vaona A |
Abstract |
Interferons (IFNs)-beta and glatiramer acetate (GA) were the first two disease-modifying therapies (DMTs) approved 15 years ago for the treatment of multiple sclerosis (MS). DMTs prescription rates as first or switching therapies and their costs have increased substantially over the past decade. As more DMTs become available, the choice of a specific DMT should reflect the risk/benefit profile, as well as the impact on quality profile. As MS cohorts enrolled in different studies can vary significantly, head-to-head trials are considered the best approach for gaining objective reliable data when two different drugs are compared. The purpose of this study is to summarise available evidence on the comparative effectiveness of IFNs-beta and GA on disease course through a systematic review of head-to-head trials. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Spain | 1 | <1% |
Turkey | 1 | <1% |
Portugal | 1 | <1% |
Unknown | 108 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 19% |
Student > Ph. D. Student | 17 | 15% |
Other | 14 | 12% |
Student > Bachelor | 9 | 8% |
Student > Master | 9 | 8% |
Other | 20 | 18% |
Unknown | 23 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 52 | 46% |
Agricultural and Biological Sciences | 7 | 6% |
Psychology | 7 | 6% |
Neuroscience | 5 | 4% |
Nursing and Health Professions | 3 | 3% |
Other | 9 | 8% |
Unknown | 30 | 27% |