| Chapter title |
Molecular Chaperones in Neurodegenerative Diseases: A Short Review
|
|---|---|
| Chapter number | 20 |
| Book title |
GeNeDis 2016
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-3-319-57379-3_20 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-957378-6, 978-3-31-957379-3
|
| Authors |
Catherine Bobori, Georgia Theocharopoulou, Panayiotis Vlamos |
| Abstract |
Stress and misfolded proteins result to dysfunction in the cell, often leading to neurodegenerative diseases and aging. Misfolded proteins form toxic aggregates that threaten cell's stability and normal functions. In order to restore its homeostasis, the cell activates the UPR system. Leading role in the restoration play the molecular chaperones which target the misfolded proteins with the purpose of either helping them to unfold and refold to their natural state or lead them degradation. This paper aims to present some of the most known molecular chaperones and their relation with diseases associated to protein misfolding and neurodegeneration, as well as the role of chaperones in proteostasis. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 22% |
| Researcher | 6 | 17% |
| Student > Ph. D. Student | 6 | 17% |
| Student > Master | 4 | 11% |
| Student > Doctoral Student | 2 | 6% |
| Other | 3 | 8% |
| Unknown | 7 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 25% |
| Agricultural and Biological Sciences | 4 | 11% |
| Neuroscience | 4 | 11% |
| Medicine and Dentistry | 3 | 8% |
| Computer Science | 2 | 6% |
| Other | 3 | 8% |
| Unknown | 11 | 31% |