Title |
Early‐life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain–gut axis dysfunction
|
---|---|
Published in |
Neurogastroenterology & Motility, December 2014
|
DOI | 10.1111/nmo.12486 |
Pubmed ID | |
Authors |
N. P. Hyland, S. M. O'Mahony, D. O'Malley, C. M. O'Mahony, T. G. Dinan, J. F. Cryan |
Abstract |
Early-life stress and a genetic predisposition to display an anxiety- and depressive-like phenotype are associated with behavioral and gastrointestinal (GI) dysfunction. Animals exposed to early-life stress, and those genetically predisposed to display anxiety or depressive behaviors, have proven useful tools in which to study stress-related GI disorders, such as irritable bowel syndrome (IBS). IBS is a heterogeneous disorder, and likely a consequence of both genetic and environmental factors. However, the combined effects of early-life stress and a genetic predisposition to display anxiety- and depression-like behaviors on GI function have not been investigated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 60% |
Ireland | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 40% |
Members of the public | 2 | 40% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 1% |
Mexico | 1 | 1% |
United States | 1 | 1% |
Portugal | 1 | 1% |
Unknown | 81 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 20% |
Student > Bachelor | 15 | 18% |
Researcher | 13 | 15% |
Student > Master | 10 | 12% |
Other | 8 | 9% |
Other | 8 | 9% |
Unknown | 14 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 21 | 25% |
Neuroscience | 13 | 15% |
Agricultural and Biological Sciences | 13 | 15% |
Psychology | 6 | 7% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Other | 9 | 11% |
Unknown | 18 | 21% |