Title |
Early‐life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain–gut axis dysfunction
|
---|---|
Published in |
Neurogastroenterology & Motility, December 2014
|
DOI | 10.1111/nmo.12486 |
Pubmed ID | |
Authors |
N. P. Hyland, S. M. O'Mahony, D. O'Malley, C. M. O'Mahony, T. G. Dinan, J. F. Cryan |
Abstract |
Early-life stress and a genetic predisposition to display an anxiety- and depressive-like phenotype are associated with behavioral and gastrointestinal (GI) dysfunction. Animals exposed to early-life stress, and those genetically predisposed to display anxiety or depressive behaviors, have proven useful tools in which to study stress-related GI disorders, such as irritable bowel syndrome (IBS). IBS is a heterogeneous disorder, and likely a consequence of both genetic and environmental factors. However, the combined effects of early-life stress and a genetic predisposition to display anxiety- and depression-like behaviors on GI function have not been investigated. |
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Demographic breakdown
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Mendeley readers
Geographical breakdown
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