| Chapter title |
Mitochondrial DNA Methylation and Related Disease
|
|---|---|
| Chapter number | 9 |
| Book title |
Mitochondrial DNA and Diseases
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-981-10-6674-0_9 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-106673-3, 978-9-81-106674-0
|
| Authors |
Danyan Gao, Bijun Zhu, Hongzhi Sun, Xiangdong Wang |
| Abstract |
Most researchers focused on methylation of genomic DNA, while methylation of mitochondrial DNA (mtDNA) is rarely tauched, and there is still controversy about the existence of mtDNA methylation. The study of cytosine methylation in mtDNA is limited. The mtDNA was recently found to exist CpG hypomethylation, and more studies provided evidence that mtDNA methylation plays an important role in mitochondrial gene regulation. In present review, we will overview recent studies of mitochondrial DNA methylation and potential influencing factors in diseases that are involved in mtDNA methylation. Thus, the further studies on mtDNA methylation will provide more evidence to explain the mechanism of mtDNA methylation and an advantageous approach for human clinical diagnosis and prevention. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 14% |
| Student > Master | 6 | 14% |
| Researcher | 6 | 14% |
| Student > Ph. D. Student | 5 | 11% |
| Professor | 4 | 9% |
| Other | 6 | 14% |
| Unknown | 11 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 27% |
| Agricultural and Biological Sciences | 6 | 14% |
| Medicine and Dentistry | 5 | 11% |
| Environmental Science | 2 | 5% |
| Neuroscience | 2 | 5% |
| Other | 4 | 9% |
| Unknown | 13 | 30% |