| Chapter title |
Metabolic Regulation in Mitochondria and Drug Resistance
|
|---|---|
| Chapter number | 11 |
| Book title |
Mitochondrial DNA and Diseases
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-981-10-6674-0_11 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-106673-3, 978-9-81-106674-0
|
| Authors |
Yue Pan, Min Cao, Jianzhou Liu, Qing Yang, Xiaoyu Miao, Vay Liang W. Go, Paul W. N. Lee, Gary Guishan Xiao |
| Abstract |
Mitochondria are generally considered as a powerhouse in a cell where the majority of the cellular ATP and metabolite productions occur. Metabolic rewiring and reprogramming may be initiated and regulated by mitochondrial enzymes. The hypothesis that cellular metabolic rewiring and reprogramming processes may occur as cellular microenvironment is disturbed, resulting in alteration of cell phenotype, such as cancer cells resistant to therapeutics seems to be now acceptable. Cancer metabolic reprogramming regulated by mitochondrial enzymes is now one of the hallmarks of cancer. This chapter provides an overview of cancer metabolism and summarizes progress made in mitochondria-mediated metabolic regulation in cancer drug resistance. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 21% |
| Student > Doctoral Student | 2 | 14% |
| Researcher | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 7 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 29% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
| Nursing and Health Professions | 1 | 7% |
| Agricultural and Biological Sciences | 1 | 7% |
| Unknown | 7 | 50% |