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Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysis

Overview of attention for article published in Anais Brasileiros de Dermatologia, June 2017
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Title
Severe cutaneous adverse drug reactions of Chinese inpatients: a meta-analysis
Published in
Anais Brasileiros de Dermatologia, June 2017
DOI 10.1590/abd1806-4841.20175171
Pubmed ID
Authors

Qiancheng Deng, Xia Fang, Qinghai Zeng, Jianyun Lu, Chen Jing, Jinhua Huang

Abstract

The rate of severe cutaneous adverse drug reactions is low, and these reactions can result in death or disability. An evidence-based epidemiological study of severe cutaneous adverse drug reactions in China has not been reported. The aim of this study was to analyze epidemiology and characteristics of severe cutaneous adverse drug reactions of Chinese inpatients during the recent 15 years with meta-analysis. We retrospectively reviewed Chinese literature reporting severe cutaneous adverse drug reactions and collecting data from 2000 to 2015, which were in accordance with our inclusion criteria. All included data were analyzed with the Launch Open Meta-Analyst software. Twenty-five articles involving 928 cases with severe cutaneous adverse drug reactions were included. Men to women ratio was 1.14:1. Twenty-one per cent of the patients had drug allergy history. Antibiotics (26.0%), sedative hypnotics and anticonvulsants (21.6%), and antipyretic analgesics (17.1%) were the most common causative drugs. The most frequent clinical subtype was Stevens-Johnson syndrome (50.1%), followed by toxic epidermal necrolysis (25.4%), exfoliative dermatitis (21.0%) and drug-induced hypersensitivity syndrome (1.6%). In addition to skin rashes, patients with severe cutaneous adverse drug reactions suffered mostly from fever (73%), and blood routine abnormality (66.7%). This meta-analysis is limited by its retrospective design and by its methodological variation. The most common causative drugs were antibiotics and sedative hypnotics and anticonvulsants. Stevens-Johnson syndrome was the most frequent clinical subtype of severe cutaneous adverse drug reactions. In addition to skin rashes, patients with severe cutaneous adverse drug reactions suffered mostly from fever, mucosal lesion, and hematologic abnormalities.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 19%
Student > Postgraduate 6 17%
Student > Doctoral Student 4 11%
Student > Bachelor 4 11%
Other 3 8%
Other 3 8%
Unknown 9 25%
Readers by discipline Count As %
Medicine and Dentistry 12 33%
Pharmacology, Toxicology and Pharmaceutical Science 6 17%
Arts and Humanities 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Veterinary Science and Veterinary Medicine 1 3%
Other 4 11%
Unknown 11 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2018.
All research outputs
#17,730,887
of 25,988,468 outputs
Outputs from Anais Brasileiros de Dermatologia
#299
of 575 outputs
Outputs of similar age
#214,394
of 334,925 outputs
Outputs of similar age from Anais Brasileiros de Dermatologia
#1
of 1 outputs
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