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Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery

Overview of attention for article published in Nature Chemistry, January 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#13 of 2,067)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
9 news outlets
blogs
2 blogs
twitter
520 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
11 Dimensions

Readers on

mendeley
152 Mendeley
Title
Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery
Published in
Nature Chemistry, January 2018
DOI 10.1038/nchem.2917
Pubmed ID
Authors

Barry A. Badeau, Michael P. Comerford, Christopher K. Arakawa, Jared A. Shadish, Cole A. DeForest

Abstract

The successful transport of drug- and cell-based therapeutics to diseased sites represents a major barrier in the development of clinical therapies. Targeted delivery can be mediated through degradable biomaterial vehicles that utilize disease biomarkers to trigger payload release. Here, we report a modular chemical framework for imparting hydrogels with precise degradative responsiveness by using multiple environmental cues to trigger reactions that operate user-programmable Boolean logic. By specifying the molecular architecture and connectivity of orthogonal stimuli-labile moieties within material cross-linkers, we show selective control over gel dissolution and therapeutic delivery. To illustrate the versatility of this methodology, we synthesized 17 distinct stimuli-responsive materials that collectively yielded all possible YES/OR/AND logic outputs from input combinations involving enzyme, reductant and light. Using these hydrogels we demonstrate the first sequential and environmentally stimulated release of multiple cell lines in well-defined combinations from a material. We expect these platforms will find utility in several diverse fields including drug delivery, diagnostics and regenerative medicine.

Twitter Demographics

The data shown below were collected from the profiles of 520 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 151 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 56 37%
Student > Bachelor 21 14%
Student > Master 17 11%
Researcher 15 10%
Unspecified 14 9%
Other 29 19%
Readers by discipline Count As %
Chemistry 45 30%
Engineering 38 25%
Unspecified 17 11%
Agricultural and Biological Sciences 12 8%
Biochemistry, Genetics and Molecular Biology 12 8%
Other 28 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 291. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2018.
All research outputs
#34,435
of 12,289,018 outputs
Outputs from Nature Chemistry
#13
of 2,067 outputs
Outputs of similar age
#2,374
of 379,376 outputs
Outputs of similar age from Nature Chemistry
#1
of 46 outputs
Altmetric has tracked 12,289,018 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,067 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 379,376 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.