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Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery

Overview of attention for article published in Nature Chemistry, January 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#37 of 3,440)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
9 news outlets
blogs
2 blogs
twitter
460 X users
patent
4 patents
facebook
1 Facebook page
video
1 YouTube creator

Citations

dimensions_citation
231 Dimensions

Readers on

mendeley
399 Mendeley
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Title
Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery
Published in
Nature Chemistry, January 2018
DOI 10.1038/nchem.2917
Pubmed ID
Authors

Barry A. Badeau, Michael P. Comerford, Christopher K. Arakawa, Jared A. Shadish, Cole A. DeForest

Abstract

The successful transport of drug- and cell-based therapeutics to diseased sites represents a major barrier in the development of clinical therapies. Targeted delivery can be mediated through degradable biomaterial vehicles that utilize disease biomarkers to trigger payload release. Here, we report a modular chemical framework for imparting hydrogels with precise degradative responsiveness by using multiple environmental cues to trigger reactions that operate user-programmable Boolean logic. By specifying the molecular architecture and connectivity of orthogonal stimuli-labile moieties within material cross-linkers, we show selective control over gel dissolution and therapeutic delivery. To illustrate the versatility of this methodology, we synthesized 17 distinct stimuli-responsive materials that collectively yielded all possible YES/OR/AND logic outputs from input combinations involving enzyme, reductant and light. Using these hydrogels we demonstrate the first sequential and environmentally stimulated release of multiple cell lines in well-defined combinations from a material. We expect these platforms will find utility in several diverse fields including drug delivery, diagnostics and regenerative medicine.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 399 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 399 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 116 29%
Student > Bachelor 51 13%
Researcher 39 10%
Student > Master 37 9%
Student > Doctoral Student 29 7%
Other 47 12%
Unknown 80 20%
Readers by discipline Count As %
Chemistry 105 26%
Engineering 56 14%
Materials Science 38 10%
Biochemistry, Genetics and Molecular Biology 24 6%
Chemical Engineering 24 6%
Other 57 14%
Unknown 95 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 287. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2024.
All research outputs
#128,890
of 26,266,075 outputs
Outputs from Nature Chemistry
#37
of 3,440 outputs
Outputs of similar age
#3,074
of 474,954 outputs
Outputs of similar age from Nature Chemistry
#1
of 46 outputs
Altmetric has tracked 26,266,075 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,440 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 474,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.