Title |
A low-protein diet during pregnancy prevents modifications in intercellular communication proteins in rat islets
|
---|---|
Published in |
Biological Research, January 2015
|
DOI | 10.1186/0717-6287-48-3 |
Pubmed ID | |
Authors |
Ana Flávia Marçal-Pessoa, Carmen Lucia Bassi-Branco, Cristiana dos Santos Barbosa Salvatierra, Luiz Fabrizio Stoppiglia, Letícia Martins Ignacio-Souza, Sílvia Regina de Lima Reis, Roberto Vilela Veloso, Marise Auxiliadora de Barros Reis, Everardo Magalhães Carneiro, Antonio Carlos Boschero, Vanessa Cristina Arantes, Márcia Queiroz Latorraca |
Abstract |
Gap junctions between β-cells participate in the precise regulation of insulin secretion. Adherens junctions and their associated proteins are required for the formation, function and structural maintenance of gap junctions. Increases in the number of the gap junctions between β-cells and enhanced glucose-stimulated insulin secretion are observed during pregnancy. In contrast, protein restriction produces structural and functional alterations that result in poor insulin secretion in response to glucose. We investigated whether protein restriction during pregnancy affects the expression of mRNA and proteins involved in gap and adherens junctions in pancreatic islets. An isoenergetic low-protein diet (6% protein) was fed to non-pregnant or pregnant rats from day 1-15 of pregnancy, and rats fed an isocaloric normal-protein diet (17% protein) were used as controls. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 4% |
Unknown | 23 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 17% |
Student > Bachelor | 3 | 13% |
Student > Postgraduate | 3 | 13% |
Student > Master | 3 | 13% |
Student > Doctoral Student | 2 | 8% |
Other | 3 | 13% |
Unknown | 6 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 17% |
Nursing and Health Professions | 3 | 13% |
Agricultural and Biological Sciences | 3 | 13% |
Engineering | 2 | 8% |
Medicine and Dentistry | 2 | 8% |
Other | 3 | 13% |
Unknown | 7 | 29% |