Chapter title |
Control of Innate Immunity by Memory CD4 T Cells
|
---|---|
Chapter number | 6 |
Book title |
Crossroads between Innate and Adaptive Immunity III
|
Published in |
Advances in experimental medicine and biology, January 2011
|
DOI | 10.1007/978-1-4419-5632-3_6 |
Pubmed ID | |
Book ISBNs |
978-1-4419-5631-6, 978-1-4419-5632-3
|
Authors |
Tara M. Strutt, K. Kai McKinstry, Susan L. Swain |
Abstract |
How memory CD4 T cells contribute to protection upon pathogen -challenge is not fully understood. Beyond traditional helper functions for CD8 T cell and B cell responses, memory CD4 T cells can have a potent impact on the character and a magnitude of inflammatory responses. Here we discuss how memory CD4 T cell control of innate immunity at early time points after pathogen encounters can influence protective responses. We also discuss important aspects of the mechanism whereby memory CD4 T cells directly and indirectly impact the activation status of antigen-presenting cells and production of inflammatory cytokines and chemokines from multiple cell types. We suggest that control of innate immune responses by the adaptive immune system is a powerful protective mechanism associated with the memory state and represents an important fail-safe in the face of pathogens that fail to trigger robust inflammatory responses through conserved pattern recognition receptors. |
Mendeley readers
Geographical breakdown
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Unknown | 36 | 95% |
Demographic breakdown
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Researcher | 7 | 18% |
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Professor | 3 | 8% |
Student > Master | 3 | 8% |
Other | 3 | 8% |
Unknown | 6 | 16% |
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