Chapter title |
Blimp1: Driving Terminal Differentiation to a T
|
---|---|
Chapter number | 8 |
Book title |
Crossroads between Innate and Adaptive Immunity III
|
Published in |
Advances in experimental medicine and biology, June 2011
|
DOI | 10.1007/978-1-4419-5632-3_8 |
Pubmed ID | |
Book ISBNs |
978-1-4419-5631-6, 978-1-4419-5632-3
|
Authors |
Xin, Annie, Nutt, Stephen L., Belz, Gabrielle T., Kallies, Axel, Annie Xin, Stephen L. Nutt, Gabrielle T. Belz, Axel Kallies |
Abstract |
B lymphocyte maturation-induced protein-1 (Blimp1) is a transcriptional repressor expressed in diverse cell types. In the adaptive immune system, Blimp1 is expressed in lymphocytes that have undergone effector differentiation. Blimp1 is a master regulator of plasma cell differentiation and plays important roles in controlling T cell homeostasis and effector differentiation. Blimp1 can be induced by a variety of cytokines including IL-2, IL-4, IL-12, and IL-21 in addition to TCR and co-stimulatory signals. Blimp1-deficient mice develop spontaneous inflammatory disease mediated by infiltration of activated T cells into tissues. During immune responses Blimp1 is required for the differentiation of plasma cells as well as short-lived CD8(+) cytotoxic T cells. Mounting evidence suggests that Blimp1 plays a common role in the terminal differentiation of multiple cell subsets. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 23% |
Researcher | 5 | 23% |
Student > Doctoral Student | 2 | 9% |
Student > Master | 2 | 9% |
Student > Bachelor | 1 | 5% |
Other | 3 | 14% |
Unknown | 4 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 8 | 36% |
Agricultural and Biological Sciences | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Nursing and Health Professions | 1 | 5% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Other | 2 | 9% |
Unknown | 5 | 23% |