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Retinal Degeneration

Overview of attention for book
Cover of 'Retinal Degeneration'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Identification and analysis of inherited retinal disease genes.
  3. Altmetric Badge
    Chapter 2 Mouse Models for Studies of Retinal Degeneration and Diseases
  4. Altmetric Badge
    Chapter 3 Retinal Fundus Imaging in Mouse Models of Retinal Diseases
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    Chapter 4 Functional Phenotyping of Mouse Models with ERG
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    Chapter 5 Phenotyping of Mouse Models with OCT
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    Chapter 6 Light Damage as a Model of Retinal Degeneration
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    Chapter 7 N -Methyl- d -Aspartate (NMDA)-Mediated Excitotoxic Damage: A Mouse Model of Acute Retinal Ganglion Cell Damage
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    Chapter 8 Generation of Transgenic X. laevis Models of Retinal Degeneration
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    Chapter 9 Analysis of Photoreceptor Degeneration in the Zebrafish Danio rerio
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    Chapter 10 Analysis of Optokinetic Response in Zebrafish by Computer-Based Eye Tracking
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    Chapter 11 Analysis of the Drosophila Compound Eye with Light and Electron Microscopy
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    Chapter 12 Cell-Specific Markers for the Identification of Retinal Cells by Immunofluorescence Microscopy
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    Chapter 13 A Method of Horizontally Sliced Preparation of the Retina
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    Chapter 14 Detection of DNA Fragmentation in Retinal Apoptosis by TUNEL
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    Chapter 15 High-Throughput RNA In Situ Hybridization in Mouse Retina
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    Chapter 16 Assessment of Mitochondrial Damage in Retinal Cells and Tissues Using Quantitative Polymerase Chain Reaction for Mitochondrial DNA Damage and Extracellular Flux Assay for Mitochondrial Respiration Activity
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    Chapter 17 Analysis of Photoreceptor Rod Outer Segment Phagocytosis by RPE Cells In Situ
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    Chapter 18 Ca 2+ Microfluorimetry in Retinal Müller Glial Cells
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    Chapter 19 Functional Analysis of Retinal Microglia and Their Effects on Progenitors
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    Chapter 20 Analysis of Photoreceptor Outer Segment Phagocytosis by RPE Cells in Culture
  22. Altmetric Badge
    Chapter 21 Ca 2+ -Imaging Techniques to Analyze Ca 2+ Signaling in Cells and to Monitor Neuronal Activity in the Retina
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    Chapter 22 Double Chromatin Immunoprecipitation: Analysis of Target Co-occupancy of Retinal Transcription Factors
  24. Altmetric Badge
    Chapter 23 Quantifying the Activity of cis -Regulatory Elements in the Mouse Retina by Explant Electroporation
  25. Altmetric Badge
    Chapter 24 Optimized Technique for Subretinal Injections in Mice
  26. Altmetric Badge
    Chapter 25 Adeno-associated viral vectors for gene therapy of inherited retinal degenerations.
  27. Altmetric Badge
    Chapter 26 Barrier Modulation in Drug Delivery to the Retina
Attention for Chapter 11: Analysis of the Drosophila Compound Eye with Light and Electron Microscopy
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Chapter title
Analysis of the Drosophila Compound Eye with Light and Electron Microscopy
Chapter number 11
Book title
Retinal Degeneration
Published in
Methods in molecular biology, January 2013
DOI 10.1007/978-1-62703-080-9_11
Pubmed ID
Book ISBNs
978-1-62703-079-3, 978-1-62703-080-9
Authors

Monalisa Mishra, Elisabeth Knust

Abstract

The Drosophila compound eye is a regular structure, in which about 750 units, called ommatidia, are arranged in a highly regular pattern. Eye development proceeds in a stereotypical fashion, where epithelial cells of the eye imaginal discs are specified, recruited, and differentiated in a sequential order that leads to the highly precise structure of an adult eye. Even small perturbations, for example in signaling pathways that control proliferation, cell death, or differentiation, can impair the regular structure of the eye, which can be easily detected and analyzed. In addition, the Drosophila eye has proven to be an ideal model for studying the genetic control of neurodegeneration, since the eye is not essential for viability. Several human neurodegeneration diseases have been modeled in the fly, leading to a better understanding of the function/misfunction of the respective gene. In many cases, the genes involved and their function are conserved between flies and human. More strikingly, when ectopically expressed in the fly eye some human genes without a Drosophila counterpart can induce neurodegeneration, detectable by aberrant phototaxis, impaired electrophysiology, or defects in eye morphology. These defects are often rather subtle alteration in shape, size, or arrangement of the cells, and can be easily scored at the ultrastructural level. This chapter aims to provide an overview regarding the analysis of the retina by various means.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 11%
Student > Ph. D. Student 1 5%
Student > Bachelor 1 5%
Student > Master 1 5%
Student > Doctoral Student 1 5%
Other 0 0%
Unknown 13 68%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 16%
Biochemistry, Genetics and Molecular Biology 2 11%
Medicine and Dentistry 1 5%
Unknown 13 68%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2014.
All research outputs
#3,126,604
of 3,908,982 outputs
Outputs from Methods in molecular biology
#1,641
of 2,655 outputs
Outputs of similar age
#77,660
of 97,571 outputs
Outputs of similar age from Methods in molecular biology
#86
of 111 outputs
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We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.