↓ Skip to main content

Chemical Biology

Overview of attention for book
Cover of 'Chemical Biology'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts.
  3. Altmetric Badge
    Chapter 2 Applying the logic of genetic interaction to discover small molecules that functionally interact with human disease alleles.
  4. Altmetric Badge
    Chapter 3 Construction and application of a photo-cross-linked chemical array.
  5. Altmetric Badge
    Chapter 4 High Content Screening for Modulators of Cardiac Differentiation in Human Pluripotent Stem Cells.
  6. Altmetric Badge
    Chapter 5 Small-Molecule High-Throughput Screening Utilizing Xenopus Egg Extract.
  7. Altmetric Badge
    Chapter 6 Fission Yeast-Based High-Throughput Screens for PKA Pathway Inhibitors and Activators.
  8. Altmetric Badge
    Chapter 7 A Method for High-Throughput Analysis of Chronological Aging in Schizosaccharomyces pombe.
  9. Altmetric Badge
    Chapter 8 Protocols for the Routine Screening of Drug Sensitivity in the Human Parasite Trichomonas vaginalis
  10. Altmetric Badge
    Chapter 9 Chemical Genetic Screens Using Arabidopsis thaliana Seedlings Grown on Solid Medium
  11. Altmetric Badge
    Chapter 10 Small-Molecule Screening Using Drosophila Models of Human Neurological Disorders.
  12. Altmetric Badge
    Chapter 11 High-Throughput Small-Molecule Screening in Caenorhabditis elegans.
  13. Altmetric Badge
    Chapter 12 Whole-Organism Screening for Modulators of Fasting Metabolism Using Transgenic Zebrafish
  14. Altmetric Badge
    Chapter 13 High Content Screening for Modulators of Cardiovascular or Global Developmental Pathways in Zebrafish
  15. Altmetric Badge
    Chapter 14 Extraction Methods of Natural Products from Traditional Chinese Medicines
  16. Altmetric Badge
    Chapter 15 Bioassay-Guided Identification of Bioactive Molecules from Traditional Chinese Medicines
  17. Altmetric Badge
    Chapter 16 NMR screening in fragment-based drug design: a practical guide.
  18. Altmetric Badge
    Chapter 17 Practical Strategies for Small-Molecule Probe Development in Chemical Biology
  19. Altmetric Badge
    Chapter 18 Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries.
  20. Altmetric Badge
    Chapter 19 Small-Molecule Library Screening by Docking with PyRx.
  21. Altmetric Badge
    Chapter 20 Fluorous Photoaffinity Labeling to Probe Protein-Small Molecule Interactions
  22. Altmetric Badge
    Chapter 21 Identification of the Targets of Biologically Active Small Molecules Using Quantitative Proteomics.
  23. Altmetric Badge
    Chapter 22 Drug Affinity Responsive Target Stability (DARTS) for Small-Molecule Target Identification.
  24. Altmetric Badge
    Chapter 23 Chemical Genomic Profiling via Barcode Sequencing to Predict Compound Mode of Action.
  25. Altmetric Badge
    Chapter 24 Image-Based Prediction of Drug Target in Yeast.
Attention for Chapter 11: High-Throughput Small-Molecule Screening in Caenorhabditis elegans.
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

Mentioned by

twitter
3 X users

Citations

dimensions_citation
76 Dimensions

Readers on

mendeley
10 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
High-Throughput Small-Molecule Screening in Caenorhabditis elegans.
Chapter number 11
Book title
Chemical Biology
Published in
Methods in molecular biology, January 2015
DOI 10.1007/978-1-4939-2269-7_11
Pubmed ID
Book ISBNs
978-1-4939-2268-0, 978-1-4939-2269-7
Authors

Sunitha Rangaraju, Gregory M Solis, Michael Petrascheck, Gregory M. Solis, Rangaraju, Sunitha, Solis, Gregory M., Petrascheck, Michael

Abstract

Chemical compounds, which modulate enzymatic activities or those which induce specific phenotypes of interest, are valuable probes to study biological phenomena, as they allow modulation of enzymatic activities and temporal control of protein action. Here, we describe the methodology to conduct large-scale screens for chemical compounds that induce a desired phenotype in the roundworm Caenorhabditis elegans (C. elegans) using 96- or 384-well microtiter plates.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 50%
Student > Ph. D. Student 1 10%
Professor > Associate Professor 1 10%
Other 1 10%
Unknown 2 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 30%
Agricultural and Biological Sciences 2 20%
Medicine and Dentistry 1 10%
Neuroscience 1 10%
Engineering 1 10%
Other 0 0%
Unknown 2 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2015.
All research outputs
#17,738,777
of 22,780,165 outputs
Outputs from Methods in molecular biology
#7,192
of 13,093 outputs
Outputs of similar age
#241,713
of 352,944 outputs
Outputs of similar age from Methods in molecular biology
#428
of 996 outputs
Altmetric has tracked 22,780,165 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,093 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,944 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 996 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.