| Chapter title |
Antibody Array as a Tool for Screening of Natural Agents in Cancer Chemoprevention
|
|---|---|
| Chapter number | 17 |
| Book title |
Cancer Chemoprevention
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3191-0_17 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3190-3, 978-1-4939-3191-0
|
| Authors |
Claudio Pulito, Andrea Sacconi, Etleva Korita, Anna Maidecchi, Sabrina Strano, Pulito, Claudio, Sacconi, Andrea, Korita, Etleva, Maidecchi, Anna, Strano, Sabrina |
| Abstract |
The efficacy of a given drug resides mainly on its ability to specifically target disease mechanisms.Natural products represent the leading source of bioactive molecules with a broad range of activities.It is becoming increasingly clear that natural compounds exert their chemopreventive or antitumoral activities targeting simultaneously diverse cellular pathways. Here we describe the use of antibody array to assess the effects of natural compounds on the expression of multiple proteins and of their posttranslational modifications in cellular systems. This might turn to be a very flexible application for cancer chemoprevention studies. |
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