Chapter title |
The Methylated DNA Immunoprecipitation [MeDIP] to Investigate the Epigenetic Remodeling in Cell Fate Determination and Cancer Development.
|
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Chapter number | 6 |
Book title |
Cancer Chemoprevention
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Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3191-0_6 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3190-3, 978-1-4939-3191-0
|
Authors |
Masciarelli, Silvia, Bellissimo, Teresa, Iosue, Ilaria, Fazi, Francesco, Silvia Masciarelli, Teresa Bellissimo, Ilaria Iosue, Francesco Fazi |
Abstract |
Epigenetic mechanisms such as DNA methylation, posttranslational modifications of histone proteins, remodeling of nucleosomes, and the expression of noncoding RNAs contribute to the regulation of gene expression for the cell fate determination and tissue development. The disruption of these epigenetic mechanisms, in conjunction with genetic alterations, is a decisive element for cancer development and progression. The cancer phenotype is characterized by global DNA hypomethylation and gene-specific hypermethylation. The methylated DNA immunoprecipitation [MeDIP] is a useful approach currently used to clarify the functional consequences of DNA methylation on cell fate determination and cancer development. |
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