| Chapter title |
Structure of the MCM2-7 Double Hexamer and Its Implications for the Mechanistic Functions of the Mcm2-7 Complex
|
|---|---|
| Chapter number | 9 |
| Book title |
DNA Replication
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-981-10-6955-0_9 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-106954-3, 978-9-81-106955-0
|
| Authors |
Yuanliang Zhai, Bik-Kwoon Tye, Zhai, Yuanliang, Tye, Bik-Kwoon |
| Abstract |
The eukaryotic minichromosome maintenance 2-7 complex is the core of the inactive MCM replication licensing complex and the catalytic core of the Cdc45-MCM-GINS replicative helicase. The years of effort to determine the structure of parts or the whole of the heterohexameric complex by X-ray crystallography and conventional cryo-EM produced limited success. Modern cryo-EM technology ushered in a new era of structural biology that allowed the determination of the structure of the inactive double hexamer at an unprecedented resolution of 3.8 Å. This review will focus on the fine details observed in the Mcm2-7 double hexameric complex and their implications for the function of the Mcm2-7 hexamer in its different roles during DNA replication. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 36% |
| Student > Doctoral Student | 2 | 18% |
| Student > Master | 2 | 18% |
| Student > Bachelor | 1 | 9% |
| Researcher | 1 | 9% |
| Other | 0 | 0% |
| Unknown | 1 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 55% |
| Agricultural and Biological Sciences | 2 | 18% |
| Chemistry | 1 | 9% |
| Medicine and Dentistry | 1 | 9% |
| Unknown | 1 | 9% |