Chapter title |
Targeted delivery of VEGF to treat myocardial infarction.
|
---|---|
Chapter number | 43 |
Book title |
Oxygen Transport to Tissue XXXIV
|
Published in |
Advances in experimental medicine and biology, January 2013
|
DOI | 10.1007/978-1-4614-4989-8_43 |
Pubmed ID | |
Book ISBNs |
978-1-4614-4771-9, 978-1-4614-4989-8
|
Authors |
Bin Wang, Rabe’e Cheheltani, Jenna Rosano, Deborah L. Crabbe, Mohammad F. Kiani, Wang, Bin, Cheheltani, Rabe’e, Rosano, Jenna, Crabbe, Deborah L., Kiani, Mohammad F. |
Abstract |
Noninvasive injection of pro-angiogenic compounds such as vascular endothelial growth factor (VEGF) has shown promising results in regenerating cardiac microvasculature. However, these results have failed to translate into successful clinical trials in part due to the short half-life of VEGF in circulation. Increasing the dose of VEGF may increase its availability to the target tissue, but harmful side-effects remain a concern. Encapsulating and selectively targeting VEGF to the MI border zone may circumvent these problems. Anti-P-selectin conjugated immunoliposomes containing VEGF were developed to target the infarct border zone in a rat MI model. Targeted VEGF therapy significantly improves vascularization and cardiac function after an infarction. |
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