| Chapter title |
Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction.
|
|---|---|
| Chapter number | 181 |
| Book title |
Ricin and Shiga Toxins
|
| Published in |
Current topics in microbiology and immunology, November 2011
|
| DOI | 10.1007/82_2011_181 |
| Pubmed ID | |
| Book ISBNs |
978-3-64-227469-5, 978-3-64-227470-1
|
| Authors |
Jandhyala DM, Magun B, Thorpe CM, Dakshina M. Jandhyala, Cheleste M. Thorpe, Bruce Magun, Jandhyala, Dakshina M., Thorpe, Cheleste M., Magun, Bruce |
| Abstract |
Shiga toxins and ricin are potent inhibitors of protein synthesis. In addition to causing inhibition of protein synthesis, these toxins activate proinflammatory signaling cascades that may contribute to the severe diseases associated with toxin exposure. Treatment of cells with Shiga toxins and ricin have been shown to activate a number of signaling pathways including those associated with the ribotoxic stress response, Nuclear factor kappa B activation, inflammasome activation, the unfolded protein response, mTOR signaling, hemostasis, and retrograde trafficking. In this chapter, we review our current understanding of these signaling pathways as they pertain to intoxication by Shiga toxins and ricin. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 4% |
| Unknown | 23 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 21% |
| Student > Bachelor | 4 | 17% |
| Student > Ph. D. Student | 4 | 17% |
| Student > Master | 3 | 13% |
| Professor | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 5 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 38% |
| Biochemistry, Genetics and Molecular Biology | 4 | 17% |
| Immunology and Microbiology | 3 | 13% |
| Social Sciences | 1 | 4% |
| Medicine and Dentistry | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 6 | 25% |