Chapter title |
Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing
|
---|---|
Chapter number | 19 |
Book title |
Hemostasis and Thrombosis
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7196-1_19 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7194-7, 978-1-4939-7196-1
|
Authors |
Kun Kan Edwin Lau, Soma Mohammed, Leonardo Pasalic, Emmanuel J. Favaloro, Lau, Kun Kan Edwin, Mohammed, Soma, Pasalic, Leonardo, Favaloro, Emmanuel J. |
Abstract |
Heparin-induced thrombocytopenia (HIT) represents a significant high morbidity complication of heparin therapy. The clinicopathological diagnosis of HIT remains challenging for many reasons; thus, laboratory testing represents an important component of an accurate diagnosis. Although there are many assays available to assess HIT, these essentially fall into two categories-(a) immunological assays, and (b) functional assays. The current chapter presents protocols for several HIT assays, being those that are most commonly performed in laboratory practice and have the widest geographic distribution. These comprise a manual lateral flow-based system (STiC), a fully automated latex immunoturbidimetric assay, a fully automated chemiluminescent assay (CLIA), light transmission aggregation (LTA), and whole blood aggregation (Multiplate). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 2 | 29% |
Student > Ph. D. Student | 1 | 14% |
Researcher | 1 | 14% |
Student > Master | 1 | 14% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 29% |
Nursing and Health Professions | 1 | 14% |
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Unknown | 3 | 43% |