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Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases

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Cover of 'Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases'

Table of Contents

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    Book Overview
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    Chapter 1 Functional Principles Implied in Neurological Symptoms
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    Chapter 2 The Neurobiology of Alzheimer’s Disease
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    Chapter 3 Role of Brain Monoamines and Other Neurotransmitters in Normal and Pathological Aging
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    Chapter 4 Molecular Genetics of Alzheimer’s Disease
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    Chapter 5 Proteins and Proteolysis in the Pathogenesis of Alzheimer’s Disease
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    Chapter 6 Amyloid β Protein Precursors having Proteinase Inhibitor Regions are Highly Expressed in Alzheimer’s Disease Brains
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    Chapter 7 Differential Expression of Three Types of Amyloid Protein Precursor mRNA in Alzheimer’s Disease Brain
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    Chapter 8 Protease Inhibitor and Cholinergic System in Alzheimer’s Disease
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    Chapter 9 Structure and Expression of mRNA for the Mouse Homolog of Alzheimer Amyloid Beta Protein Precursor
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    Chapter 10 Molecular Cloning and Structural Analysis of the Human Amyloid ß Protein Precursor Gene
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    Chapter 11 Protease Nexin 1 Immunoreactivity in Senile Plaques in Alzheimer Disease and Aged Brain
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    Chapter 12 Monoclonal Antibodies Against Senile Plaque Amyloid in Alzheimer’s Disease
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    Chapter 13 Identification of Putative Amyloid A4-Splitting Enzymes with Two Endopeptidases Widely Distributed in Mammalian Cells
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    Chapter 14 Proteolytic Processing of β-Protein Precursor-Related Synthetic Peptides
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    Chapter 15 Degeneration of Neuronal Processes in Rats Induced by the Protease Inhibitor Leupeptin
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    Chapter 16 α 1-Antichymotrypsin Influences the Survival of Neurons
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    Chapter 17 Evidence for a Neuronal Origin of Senile Plaques in Down’s Syndrome Brains
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    Chapter 18 Serum Amyloid P Immunoreactivity in Cortical Tangles, Plaques and Vessels in Alzheimer’s Disease: Implications for Dysfunction of the Blood-Brain Barrier?
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    Chapter 19 Monoamine Oxidase B Activity in Senile Plaque
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    Chapter 20 Light and Electron Microscopic Observations of Diffuse Plaque and Its Related Conditions
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    Chapter 21 β-Amyloid Plaques and Dementia: An Immunohistochemical Study
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    Chapter 22 Diagnosis of Cerebral Amyloid Angiopathy with Cerebral Hemorrhage by Enzyme-Linked Immunosorbent Assay (ELISA) of Cystatin C in Cerebrospinal Fluid
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    Chapter 23 Cystatin C (γ-Trace) and β-Protein Coexist in the Cerebral Amyloid Angiopathy Causing Cerebral Hemorrhage and Consequential Vascular Dementia
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    Chapter 24 The Regulation of Cytoskeletal Elements in Differentiating Human Neuroblastoma and Rat Pheochromocytoma PC-12 Cells
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    Chapter 25 Some Findings on Intermediate Filaments in Alzheimer’s Disease
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    Chapter 26 A Unifying Hypothesis on the Etiology of Alzheimer’s Disease
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    Chapter 27 Abnormal Phospholipid Metabolism in Neurodegenerative Diseases: Elevations in Glycerophosphocholine and Glycerophospho-Ethanolamine Levels in Brain of Alzheimer’s Disease But Not in Down Syndrome Patients
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    Chapter 28 Alterations in Catecholamine and Peptide Neurons in the Locus Coeruleus in Dementias of Alzheimer’s and Parkinson’s Disease
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    Chapter 29 The Role of Neuronal Membranes Deterioration in The Pathogenesis of Alzheimer’s Disease: An Ultrastructural Perspective
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    Chapter 30 Experimental Synaptic Degeneration as a Model for the Pathogenesis of Alzheimer’s Disease: Monoclonal Antibodies and a Protein Kinase Inhibitor Block Synapse Formation and Maintenance Between Cultured CNS Neurons
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    Chapter 31 Pathobiochemical Aspects of Parkinson’s Disease and Dementia of Alzheimer Type
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    Chapter 32 Characterization of Alzheimer Neurofibrillary Tangle (NFT) Epitopes and the Binding Site for the Regulatory Subunit (RII) of cAMP-Dependent Protein Kinase II in Human Microtubule-Associated Protein 2 (MAP-2)
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    Chapter 33 Identification and Characterization of Modified Forms of Tau in Brains with Alzheimer’s Disease
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    Chapter 34 Phosphorylation of Tau Protein with a Novel Tau Protein Kinase Forming Paired Helical Filament Epitopes on Tau
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    Chapter 35 Aberration of Vimentin Array in Fibroblast from Familial Alzheimer’s Disease
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    Chapter 36 Regional Phospholipid Profile of Alzheimer’s Brain
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    Chapter 37 Age-Related Changes in the Rate and Composition of the Slow Axonal Transport
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    Chapter 38 Astroglial Gene Expression in the Hippocampus Following Partial Deafferentation in the Rat and in Alzheimer’s Disease
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    Chapter 39 Blood-Brain Barrier Disturbance in Patients with Alzheimer’s Disease is Related to Vascular Factors
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    Chapter 40 An Early Change of Neurofibrillary Tangle Formation
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    Chapter 41 Monoclonal Antibodies Against Paired Helical Filament in Alzheimer’s Disease and Parkinsonism-Dementia Complex of Guam
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    Chapter 42 Patterns of Vulnerability of Mesostriatal Neurons
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    Chapter 43 Complex I Deficiency in Parkinson’s Disease and MPTP-Induced Experimental Parkinsonism
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    Chapter 44 Biochemical Reactions Leading to Parkinsonian Symptoms Elicited by MPTP
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    Chapter 45 Enzymological Aspects of the Actions of the Parkinsonism-Inducing Neurotoxin MPTP
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    Chapter 46 Biochemical Studies on Predisposition to Parkinson’s Disease
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    Chapter 47 Parkinsoism Produced by an Endogenous Substance, Tetrahydroisoquinoline, in Monkeys and Mice
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    Chapter 48 Tetrahydroisoquinoline Alkaloids in Neurodegenerative Disorders - Influence of Drug Treatment
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    Chapter 49 Chronic L-Dopa Therapy in Parkinson’s Disease: Can It Accelerate Degeneration of Nigrostriatal Dopaminergic Neurons?
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    Chapter 50 Iron-Melanin Interaction in Substantia Nigra as the Neurotoxic Component of Parkinson’s Disease
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    Chapter 51 Dopamine Immunocytochemistry in the Nigrostriatal System of Pre- and Postnatal Mice
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    Chapter 52 The Effects of N-Metyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration to Maternal Mice on the Catecholamine System in the Brain of Postnatal Mice
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    Chapter 53 Mitochondrial Abnormalities in the Nigral Neurons of Crab-Eating Monkeys with Experimental Parkinsonism
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    Chapter 54 L-DOPA-Induced Facilitation of Dopamine Release VIA Presynaptic β-Adrenoceptors in Striatal Slices from MPTP-Treated C57BL Mice: Evaluation of the Action of L-DOPA in Animal Model for Parkinsonism
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    Chapter 55 Functional Alterations in Striatal Cholinergic and Striato-Nigral Gaba-Ergic Neurons Following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration
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    Chapter 56 Hemiparkinsonism in Monkeys After Unilateral Striatum Infusion of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)
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    Chapter 57 Cyclosporin a Enhances Neurotoxicity of N-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in Mice
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    Chapter 58 Effects of Various Drugs on Behavior and Striatal Dopamine Contents in MPTP-Treated Mice Exposed to Stress
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    Chapter 59 Acute Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) on Body Temperature of Various Strains of Mice
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    Chapter 60 Effect of MPP + and TIQ on Cultured Rat Midbrain Dopaminergic Neurons
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    Chapter 61 Assay System for Neurotoxicants Causing Parkinson’s Disease: 1-Methyl-4-Phenylpyridinium Ion (MPP + ) Inhibits Survival of Cultured Neurons from Substantia Nigra of Fetal Monkey( Macaca fascicularis )
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    Chapter 62 The Effect of Tetrahydroisoquinoline on the Mitochondrial Respiration
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    Chapter 63 Detection of Tetrahydroisoquinoline, a Parkinsonism-Related Compound, in Parkinsonian Brains and Foods by Gas Chromatography-Mass Spectrometry
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    Chapter 64 Biosynthesis of N-Methylisoquinolinium Ion, a Potent Inhibitor of Catecholamine Metabolism, from 1,2,3,4-Tetrahydroisoquinoline Through N-Methyl-1,2,3,4-Tetrahydroisoquinoline in Human Brain
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    Chapter 65 Importance of 1-Methyltetrahydroisoquinoline (1MeTIQ) in Parkinson’s Disease
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    Chapter 66 Formation of a Novel and Neurotoxic Tetrahydroisoquinoline Derivative, 1,3-Dimethyltetrahydroisoquinoline (1, 3DiMeTIQ), a Condensation Product of Amphetamines and Acetaldehyde in Vivo
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    Chapter 67 Tryptophan Metabolites in Parkinson’s Brain
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    Chapter 68 A Parallel Relationship between Parkinson’s Disease and an Excess of S-Adenosylmethionine-Dependent Biological Methylation in the Brain
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    Chapter 69 Dopa and Dopamine Cause the Destruction of Cultured Nerve Cells in the Presence of Iron: Possible Mechanism of the Nigral Degeneration in Parkinson’s Disease
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    Chapter 70 Food-Derived Heterocyclic Amines as Potent Inhibitors of Catecholamine Metabolism
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    Chapter 71 Senile Changes in the Human Olfactory Bulbs
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    Chapter 72 Large Neurons in the Neostriatum and Basal Nucleus of Meynert: Simultaneous Decrease in Alzheimer’s Disease
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    Chapter 73 A Comparison of “Pure” Alzheimer’s Disease and Alzheimer’s Disease Plus Vascular Lesions (Mixed Dementia) in the Elderly
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    Chapter 74 Choline Acetyltransferase and Substance P Level in Alzheimer’s Disease and Multi-Infarct Dementia
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    Chapter 75 A Study on Postmortem Changes in Vasopressin mRNA in Rat Brain Using a Non-Isotopic Method
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    Chapter 76 Topographical Distribution, Fine Structure of Component Fibrils, and Immunoreactivity of Neuronal Inclusions in Alzheimer’s, Parkinson’s, and Pick’s Diseases
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    Chapter 77 Neuronal Loss in the Substantia Nigra and Ventral Tegmental Area in Parkinson’s Disease and Alzheimer’s Disease
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    Chapter 78 Characteristics of Reactive Microglia in Alzheimer’s and Parkinson’s Disease Brain Tissue
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    Chapter 79 Alzheimer - Parkinson Disease Spectrum and Diffuse Lewy Body Disease
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    Chapter 80 Acetylcholinesterase Histochemical Changes in the Cerebral Cortex of Alzheimer’s Disease
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    Chapter 81 Basement Membrane Components in Alzheimer’s Disease
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    Chapter 82 Regulation of Cerebral Cortical and Hippocampal Blood Flow by Cholinergic Fibers Originating in the Nucleus Basalis of Meynert and Septal Complex
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    Chapter 83 Immune System Reaction to Model Lesions of Rat Brain
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    Chapter 84 Computer-Aided Quantitative Analysis of the Distribution of Catecholamine-Containing Fibers in the Primate Prefrontal Cortex
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    Chapter 85 Nigrostriatal Loop Disruption in Parkinson’s Disease and Striatonigral Degeneration
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    Chapter 86 Immunocytochemical Studies of Substance P and Met-Enkephalin in the Globus Pallidus of Progressive Supranuclear Palsy
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    Chapter 87 Heterogeneous Distribution of L-DOPA Immunoreactivity in Dopaminergic Neurons of the Rat Midbrain
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    Chapter 88 Cholinergic Systems in Alzheimer’s Disease, Parkinson’s Disease and Progressive Supranuclear Palsy
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    Chapter 89 Neurochemical Aspects of Parkinson’s Disease and the Dementing Brain Disorders: Relation to Brain Ageing
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    Chapter 90 Neuropharmacology and Functional Anatomy of the Basal Ganglia: Experimental Models for Parkinson’s and Alzheimer’s Disease
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    Chapter 91 Neurotransmitter Changes in Alzheimer-Type Dementia and Therapeutic Strategies
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    Chapter 92 In Vitro Experimental Approach for Determination of the Central Cholinergic Neuronal Activity
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    Chapter 93 Pharmacological Profile of Brain Glucose Utilization Obtained by Monitoring of Lactate Release in Vivo under the Free Moving Condition
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    Chapter 94 Behavioral and Neurochemical Evaluation of Stroke-Prone Spontaneously Hypertensive Rats for Vascular Dementia-Animal Model
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    Chapter 95 Acetylcholinesterase of Cerebral Microvessels Changes in Alzheimer’s Disease
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    Chapter 96 Genes of Human Catecholamine-Synthesizing Enzymes
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    Chapter 97 Gene Activity and Neurodegeneration in the Extrapyramidal System: A Progress Report on Molecular and Morphological Correlates
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    Chapter 98 Analysis of Dopamine and Neuropeptides in 6-OHDA-Lesioned Rats
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    Chapter 99 Enhancement of in Vivo Dopamine Release from the Rat Striatum by 6R-L-Erythro-5,6,7,8-Tetrahydrobiopterin as Studied by Brain Dialysis
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    Chapter 100 Preparation of Antigen and Antibody to 3-Methoxy-4-Hydroxyphenyl Glycol(MHPG)
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    Chapter 101 Study of Central Putative Neurotransmitters in Rodent Models of Parkinsonism
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    Chapter 102 Possible Factors Responsible for Adverse Effects of Long-Term L-Dopa Therapy: Simultaneous Determinations of Dopamine Parameters in Rats
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    Chapter 103 Generating and Controlling Multiparameter Data Bases for Biochemical Correlates of Disorders
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    Chapter 104 NEUBA ® : A Multicolumn, Multidetector Liquid Chromatograph with Electrochemical Detection for Use in the Identification and Determination of Neurochemicals and Related Species
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    Chapter 105 Examination of Central Nervous System Effects of Amphetamine Using NEUBA ®
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    Chapter 106 Application of Multi-Dimensional Liquid Chromatography (NEUBA ® ) to the Determination of Neuronal Changes in an Organism
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    Chapter 107 Patterns of Tyrosine and Tryptophan Metabolites in Controls and Various Degenerative Disorders
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    Chapter 108 Dementia in Parkinson’s Disease and Central Cholinergic Function
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    Chapter 109 Subtypes of Nicotinic Receptors in Human Cortex: Selective Changes in Alzheimer Disease
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    Chapter 110 Alterations in Muscarinic Cholinergic Receptors and the Second Messenger System in the Cerebral Cortex in Alzheimer-Type Dementia
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    Chapter 111 Expression of Nicotinic Acetylcholine Receptor mRNA in the Rat Cerebral Cortex after Lesioning of the Nucleus Basalis Magnocellularis
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    Chapter 112 Studies of Central Nervous System Cholinergic Receptors in Alzheimer’s Disease (AD)
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    Chapter 113 Cerebellar Excitatory Amino Acid Binding Sites are Differentially Altered in Alzheimer’s Disease
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    Chapter 114 Pre- and Postsynaptic Cortical Glutamatergic Binding Sites in Alzheimer’s Disease
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    Chapter 115 Reduced N-Methyl-D-Aspartate (NMDA) Receptor-Ion Channel Complex in Alzheimer’s Disease Frontal Cortex
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    Chapter 116 The Influence of Priming on the Behavioral Expression of Dopamine Receptor Supersensitivity in Basal Ganglia
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    Chapter 117 M1 Receptors Stimulate Dopamine Release Via Protein Kinase C in the Striatum of Freely Moving Rat Studied by Brain Dialysis
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    Chapter 118 Effect of MPTP on Dopamine D 2 Receptors in the Aging Mouse Striatum
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    Chapter 119 Age-Dependent Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in the Rat
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    Chapter 120 More Rapid Development of Supersensitivity of D-2 Receptors than D-1 Receptors as Examined by Rotational Behavior
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    Chapter 121 Features of the Dopaminergic Neurotoxicity of Methamphetamine: A Comparison with MPTP
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    Chapter 122 Alteration of [ 3 H] Ins (1,4,5) P 3 and [ 3 H] PDBu Binding Sites in Brains of Patients with Parkinson’s Disease and Multiple System Atrophy
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    Chapter 123 The Mechanism of Action of Nerve Growth Factor
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    Chapter 124 Nerve Growth Factor Promotes Survival of Cultured Cholinergic Neurons from Nucleus Basalis of Meynert of 2-Week-Old Rats
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    Chapter 125 Alterations in Nerve Growth Factor Receptor Containing Neurons in Parkinson’s Disease
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    Chapter 126 A Striatal-Derived DA Neuron Growth Factor: Implication in Parkinson’s Disease
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    Chapter 127 Co-Localization of Cholinergic and GABAergic Traits in in Vitro Septohippocampal Neurons from Developing Rats
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    Chapter 128 A Hippocampal Cell Line Expresses a Membrane-Associated Cholinergic Trophic Activity Not Attributable to Nerve Growth Factor
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    Chapter 129 Interleukin-6 as a Neurotrophic Factor for Promoting Survival of Septal Cholinergic Neurons and Mesencephalic Catecholaminergic Neurons from Postnatal Rats
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    Chapter 130 Distribution of NGF Receptors in Control and Alzheimer’s Disease Basal Forebrain
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    Chapter 131 Trophic Effects of Hippocampus Cell Membrane Fragments on Cultured Medial Septal Cholinergic Neurons
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    Chapter 132 Changes in Basal Forebrain Cholinergic Systems Following Excitotoxic Cell Death in the Hippocampus and Cerebral Neocortex
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    Chapter 133 Interleukin-3 Promotes Neurite Outgrowth and Elevates Choline Acetyltransferase Activity
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    Chapter 134 Memory Impairment in Rats Induced by an Active Fragment of Nerve Growth Factor Antibody
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    Chapter 135 Brain’s Calculating Principle
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    Chapter 136 Screening for Psychotherapeutic Chemicals by Analysis of Conscious Activity in the Mouse
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    Chapter 137 Regulation of Neocortical Electrical Activity by Cholinergic and Noradrenergic Systems
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    Chapter 138 Ascending Cholinergic and Monoaminergic Systems in the Brainstem: Do they Constitute a Reticular Activating System?
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    Chapter 139 Role of the Medial Limbic System in the Memory Process: A Hypothesis Based on a Radioactive 2-Deoxyglucose Study
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    Chapter 140 Effect of Magnetism on Learning Function
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    Chapter 141 Morphological Changes of the Brain in Senescence Accelerated Mouse (SAM)-P/8, a Newly Developed Memory-Deficient Strain
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    Chapter 142 Age-Related Changes in Blood-Brain Barrier ( BBB )
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    Chapter 143 Effect of Aging on NADPH-Diaphorase Neurons in Laterodorsal Tegmental Nucleus and Striatum of Senescence Accelerated Mouse (SAM)
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    Chapter 144 Senescence-Accelerated Mouse SAM-P/8 Shows Spontaneous Age-Related Impairment of Ability of Acquisition of Learning and Memory: An Animal Model of Disturbances in Recent Memory with Aging
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    Chapter 145 An Experimental Animal Model for the Study of Cholinergic and Serotonergic Neuronal Activity in Aging Brain
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    Chapter 146 Aging Effects on Schedule-Control Discrimination Learning Test in Aged Rats as a Model of Alzheimer’s Disease
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    Chapter 147 Effect of the Basal Forebrain Lesions on Memory and Learning Performance in Mice
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    Chapter 148 Effects of Destruction of Nucleus Basalis Meynert on Operant Study and Neurotransmitters in Rats
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    Chapter 149 Characteristic of Learning Deficit Induced by Ibotenic Acid Lesion of the Frontal Cortex Related with the Nucleus Basalis of Meynert in Rats
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    Chapter 150 A New Animal Model of Alzheimer’s Disease by Selective Destruction of the Cholinergic Neurons in the Basal Forebrain
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    Chapter 151 Impairment of Avoidance Behavior Produced by Destruction of the Cholinergic Projection from the Pedunculopontine Nucleus to the Medial Thalamus
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    Chapter 152 Impaired Spatial Learning in Rats with a Trimethyltin-Induced Hippocampal Lesion and the Effect of Fetal Septal Grafting on the Impairment
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    Chapter 153 Some Effects of CNS Cholinergic Neurons on Memory and ACh Release
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    Chapter 154 Carbon Monoxide (CO)-Induced Delayed Amnesia and Delayed Neuronal Death
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    Chapter 155 Modifications in the Levels of Antibodies in the CSF of Parkinson’s Disease Patients Following Adrenal-to-Brain Transplantation
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    Chapter 156 Autotransplantation of Parasympathetic Cholinergic Neurons into Alzheimer Model Rat Brain
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    Chapter 157 Use of MPTP-Hemiparkinsonian (HP) Monkeys to Evaluate Efficacy of Tissue Implants as a Treatment for Parkinson’s Disease
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    Chapter 158 Autotransplantation of Sympathetic Ganglion into the Brain of Parkinsonian Monkey
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    Chapter 159 Long-Term Survival of Grafted Cells, Dopamine Synthesis/Release, Receptor Activity, and Functional Recovery after Grafting of Fetal Nigral Cells in Model Animals of Hemi-Parkinson’s Disease
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    Chapter 160 Intra-Accumbens Dopaminergic Grafts Restore Methamphetamine-Induced Locomotor Hyperactivity Response and the Release and Metabolism of Dopamine in Rats Having 6-OHDA Lesions in the Ventral Tegmental Area
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    Chapter 161 Investigation of MHC Antigens on Neural Graft in Mouse Parkinson’s Models
Attention for Chapter 104: NEUBA ® : A Multicolumn, Multidetector Liquid Chromatograph with Electrochemical Detection for Use in the Identification and Determination of Neurochemicals and Related Species
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Chapter title
NEUBA ® : A Multicolumn, Multidetector Liquid Chromatograph with Electrochemical Detection for Use in the Identification and Determination of Neurochemicals and Related Species
Chapter number 104
Book title
Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases
Published by
Springer, Boston, MA, January 1990
DOI 10.1007/978-1-4684-5844-2_104
Book ISBNs
978-1-4684-5846-6, 978-1-4684-5844-2
Authors

D. J. Turk, C. LeRoy Blank