Chapter title |
Single intravenous dose kinetics accumulation of atenolol in patients with impaired renal function and on hemodialysis.
|
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Chapter number | 79 |
Book title |
Further Studies in the Assessment of Toxic Actions
|
Published in |
Archives of toxicology Supplement Archiv für Toxikologie Supplement, January 1980
|
DOI | 10.1007/978-3-642-67729-8_79 |
Pubmed ID | |
Book ISBNs |
978-3-54-010191-8, 978-3-64-267729-8
|
Authors |
W Kirch, M Schäfer, M Braun, Kirch, W, Schäfer, M, Braun, M, Kirch, W., Schäfer, M., Braun, M., W. Kirch, M. Schäfer, M. Braun |
Abstract |
The concentration of atenolol in plasma and urine was determined following an intravenous (i.v.) dose given to 17 hypertensive patients with a glomerular filtration rate (GFR) between 5 and 105 ml/min and in 4 patients on hemodialysis. In patients with normal renal function the mean half life of elimination was calculated to be 6.8 h. This value increased to a mean of 50.1 h in patients with a GFR below 10 ml/min. In patients on hemodialysis the half life of elimination was about 4 h. The elimination rate constants as well as the body and renal clearances of atenolol have a significant correlation with the GFR. Although accumulation of atenolol was observed, especially after multiple oral doses and in patients with a GFR below 30 ml/min, no toxic side effects occurred. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 2 | 100% |
Readers by discipline | Count | As % |
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Mathematics | 1 | 50% |
Chemistry | 1 | 50% |