Chapter title |
The effect of high concentrations of oxygen on paraquat and diquat toxicity in rats.
|
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Chapter number | 95 |
Book title |
Further Studies in the Assessment of Toxic Actions
|
Published in |
Archives of toxicology Supplement Archiv für Toxikologie Supplement, January 1980
|
DOI | 10.1007/978-3-642-67729-8_95 |
Pubmed ID | |
Book ISBNs |
978-3-54-010191-8, 978-3-64-267729-8
|
Authors |
I. S. Pratt, P. L. Keeling, L. L. Smith, Pratt, I. S., Keeling, P. L., Smith, L. L. |
Abstract |
High concentrations of oxygen are known to enhance the toxic effects of paraquat in the lung. We have examined the effects of paraquat (2.5 mg/kg or 20 mg/kg subcutaneously) and diquat (10 mg/kg or 20 mg/kg subcutaneously) on mortality and lung pathology in rats exposed to air or to an atmosphere of 85% oxygen. Our results show a 10-fold increase in mortality when paraquat is given to rats placed in 85% oxygen rather than air, but only a 2-fold increase in the lethality of diquat. Lung damage typical of early paraquat intoxication is seen following 20 mg/kg paraquat in air or oxygen, with damage to type I and type II alveolar cells. Selective damage to the type II cell is produced by lower levels of paraquat (2.5 mg/kg) and by 20 mg/kg diquat, both in 85% oxygen, other cell types showed little change. Lung damage is minimal following 2.5 mg/kg paraquat or 20 mg/kg diquat in air, or exposure to 85% oxygen alone. It is suggested that the type II cell may be the primary target cell for paraquat and diquat in the lung. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 1 | 20% |
Student > Bachelor | 1 | 20% |
Researcher | 1 | 20% |
Other | 1 | 20% |
Unknown | 1 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 2 | 40% |
Agricultural and Biological Sciences | 1 | 20% |
Environmental Science | 1 | 20% |
Unknown | 1 | 20% |