Chapter title |
Identification and isolation of CD1a positive putative tumour infiltrating dendritic cells in human breast cancer.
|
---|---|
Chapter number | 92 |
Book title |
Dendritic Cells in Fundamental and Clinical Immunology
|
Published in |
Advances in experimental medicine and biology, January 1997
|
DOI | 10.1007/978-1-4757-9966-8_92 |
Pubmed ID | |
Book ISBNs |
978-1-4757-9968-2, 978-1-4757-9966-8
|
Authors |
Brendon J. Coventry, Jonathan M. Austyn, Steve Chryssidis, Debra Hankins, Adrian Harris |
Abstract |
Identification of dendritic cells (DC) in human tissues has been technically problematic due to the lack of truly specific immunohistochemical markers for DC's. Human dendritic cells express CD1a glycoprotein at certain points in their life cycle. CD1a positive cells are present in many human tumours and have been associated with improved survival. However, little information exists concerning the separation of DC from human tumours. The current study reports that human breast carcinomas have low densities of CD1a positive cells with dendritic morphology, and details are shown of a technique for successful separation of these cells from tumour tissues. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 2 | 15% |
Professor > Associate Professor | 2 | 15% |
Researcher | 2 | 15% |
Student > Ph. D. Student | 2 | 15% |
Other | 1 | 8% |
Other | 2 | 15% |
Unknown | 2 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 4 | 31% |
Medicine and Dentistry | 3 | 23% |
Agricultural and Biological Sciences | 2 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 15% |
Unknown | 2 | 15% |