| Chapter title |
The Biology and Functions of Th22 Cells.
|
|---|---|
| Chapter number | 8 |
| Book title |
T Helper Cell Differentiation and Their Function
|
| Published in |
Advances in experimental medicine and biology, September 2014
|
| DOI | 10.1007/978-94-017-9487-9_8 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-179486-2, 978-9-40-179487-9
|
| Authors |
Jia L, Wu C, Lei Jia, Changyou Wu, Jia, Lei, Wu, Changyou |
| Abstract |
T helper (Th) cells develop from naïve CD4(+) T cells under lineage-specific culture conditions and are nominated by their lineage-specific cytokines. Th22 cells, new players in adoptive immune responses, are identified by the production of interleukin (IL)-22. Plenty of observations are obtained over the past few years indicating that IL-22 is produced by activated T cells including Th22 cells, Th17 cells, Th1 cells, innate lymphoid cells and some nonlymphocytes. IL-22 functions synergistically with IL-17 or tumor necrosis factor (TNF), however, it plays different roles by IL-22/IL-22 receptor signal transductions in pathologic processes, including inflammations, autoimmunity, tumor, and digestive organs damages. In this chapter, we focus on the biology of IL-22, the generation and regulation of Th22 cells, the possible signal pathways that involved in the functions of Th22 cells, as well as the relationship between Th22 cells and various diseases. |
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Mendeley readers
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