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Mendeley readers
Chapter title |
Cell Fusion Between Dendritic Cells and Whole Tumor Cells
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Chapter number | 13 |
Book title |
Cell Fusion
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Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-2703-6_13 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2702-9, 978-1-4939-2703-6
|
Authors |
Shigeo Koido, Jianlin Gong, Koido, Shigeo, Gong, Jianlin |
Abstract |
We have developed cell fusion vaccines generated with dendritic cells (DCs) and whole tumor cells to induce antigen-specific antitumor immunity. This approach allows DCs to be exposed to the entire repertoire of tumor-associated antigens (TAAs) originally expressed by the tumor cell, to process them endogenously, and to present antigenic epitopes thought the MHC class I and class II pathways to activate both CD8+ and CD4+ T cells, respectively. The therapeutic efficacy of DC/tumor fusion cell vaccines requires the improved immunogenicity of both cells. Here, we describe the strategy to generate DC/tumor fusion cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 1 | 50% |
Student > Master | 1 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 1 | 50% |
Neuroscience | 1 | 50% |