Report for: Histone Deacetylases

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Chapter title	Histone Deacetylases
Chapter number	21
Book title	Histone Deacetylases
Published in	Methods in molecular biology, January 2016
DOI	10.1007/978-1-4939-3667-0_21
Pubmed ID	27246224
Book ISBNs	978-1-4939-3665-6, 978-1-4939-3667-0
Authors	Ciarlo, Eleonora, Roger, Thierry, Eleonora Ciarlo, Thierry Roger
Abstract	The development and screening of pharmacological modulators of histone deacetylases (HDACs), and particularly sirtuins, is a promising field for the identification of new drugs susceptible to be used for treatment strategies in a large array of welfare-associated, autoimmune and oncologic diseases. Here we describe a comprehensive protocol to evaluate the impact of sirtuin-targeting drugs on inflammatory and innate immune responses in vitro and in a preclinical mouse model of endotoxemia. We first provide an overview on strategies to design in vitro experiments, then focus on the analysis of cytokine production by primary macrophages and RAW 267.7 macrophages at the mRNA and protein levels, and finally describe the setup and follow-up of a mouse model of inflammation-driven endotoxic shock.

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Country	Count	As %
Unknown	1	100%

Demographic breakdown

Type	Count	As %
Members of the public	1	100%

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	6	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Master	2	33%
Researcher	1	17%
Professor	1	17%
Unknown	2	33%

Readers by discipline	Count	As %
Medicine and Dentistry	3	50%
Veterinary Science and Veterinary Medicine	1	17%
Unknown	2	33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2016.

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#20,330,976

of 22,875,477 outputs

Outputs from Methods in molecular biology

#9,917

of 13,131 outputs

Outputs of similar age

#330,739

of 393,698 outputs

Outputs of similar age from Methods in molecular biology

#1,054

of 1,471 outputs

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So far Altmetric has tracked 13,131 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.

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Histone Deacetylases

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Geographical breakdown

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