Title |
Were arachnids the first to use combinatorial peptide libraries?
|
---|---|
Published in |
Regulatory Peptides, January 2005
|
DOI | 10.1016/j.peptides.2004.07.016 |
Pubmed ID | |
Authors |
Brianna L. Sollod, David Wilson, Olga Zhaxybayeva, J. Peter Gogarten, Roger Drinkwater, Glenn F. King |
Abstract |
Spiders, scorpions, and cone snails are remarkable for the extent and diversity of gene-encoded peptide neurotoxins that are expressed in their venom glands. These toxins are produced in the form of structurally constrained combinatorial peptide libraries in which there is hypermutation of essentially all residues in the mature-toxin sequence with the exception of a handful of strictly conserved cysteines that direct the three-dimensional fold of the toxin. This gene-based combinatorial peptide library strategy appears to have been first implemented by arachnids almost 400 million years ago, long before cone snails evolved a similar mechanism for generating peptide diversity. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Australia | 2 | 2% |
Italy | 1 | <1% |
Canada | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 115 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 20% |
Student > Master | 21 | 17% |
Researcher | 20 | 16% |
Professor | 9 | 7% |
Student > Postgraduate | 8 | 7% |
Other | 24 | 20% |
Unknown | 16 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 57 | 46% |
Biochemistry, Genetics and Molecular Biology | 21 | 17% |
Chemistry | 7 | 6% |
Immunology and Microbiology | 3 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 11 | 9% |
Unknown | 21 | 17% |