Title |
Impact on mortality and cancer incidence rates of using random invitation from population registers for recruitment to trials
|
---|---|
Published in |
Trials, March 2011
|
DOI | 10.1186/1745-6215-12-61 |
Pubmed ID | |
Authors |
Matthew Burnell, Aleksandra Gentry-Maharaj, Andy Ryan, Sophia Apostolidou, Mariam Habib, Jatinderpal Kalsi, Steven Skates, Mahesh Parmar, Mourad W Seif, Nazar N Amso, Keith Godfrey, David Oram, Jonathan Herod, Karin Williamson, Howard Jenkins, Tim Mould, Robert Woolas, John Murdoch, Stephen Dobbs, Simon Leeson, Derek Cruickshank, Stuart Campbell, Lesley Fallowfield, Ian Jacobs, Usha Menon |
Abstract |
Participants in trials evaluating preventive interventions such as screening are on average healthier than the general population. To decrease this 'healthy volunteer effect' (HVE) women were randomly invited from population registers to participate in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) and not allowed to self refer. This report assesses the extent of the HVE still prevalent in UKCTOCS and considers how certain shortfalls in mortality and incidence can be related to differences in socioeconomic status. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 20% |
Student > Master | 5 | 10% |
Student > Bachelor | 5 | 10% |
Student > Ph. D. Student | 4 | 8% |
Student > Postgraduate | 4 | 8% |
Other | 10 | 20% |
Unknown | 12 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 40% |
Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Agricultural and Biological Sciences | 6 | 12% |
Nursing and Health Professions | 2 | 4% |
Psychology | 2 | 4% |
Other | 4 | 8% |
Unknown | 10 | 20% |