Chapter title |
Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A
|
---|---|
Chapter number | 21 |
Book title |
Hemostasis and Thrombosis
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7196-1_21 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7194-7, 978-1-4939-7196-1
|
Authors |
Susan Rodgers, Elizabeth Duncan, Rodgers, Susan, Duncan, Elizabeth |
Abstract |
Hemophilia A is an inherited bleeding disorder caused by a reduced level of factor VIII coagulant activity (FVIII:C) in blood. Bleeding episodes may occur spontaneously in the severe form of hemophilia or after trauma in the milder forms. It is important that patients are diagnosed correctly, which includes placing them into the correct severity category of the disorder so that appropriate treatment can be given. Diagnosis is made by determination of the amount of FVIII:C in the blood, usually using a one-stage factor VIII:C assay. However, approximately one third of patients with mild or moderate hemophilia will have much lower results by the chromogenic assay, with some of them having normal results by the one-stage assay. The chromogenic factor VIII assay is used in some specialized hemophilia reference centers and is recommended for the diagnosis of mild hemophilia A, as this assay is considered to better reflect the severity status of hemophilia patients than the one-stage assay. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 24% |
Researcher | 2 | 12% |
Other | 1 | 6% |
Student > Ph. D. Student | 1 | 6% |
Student > Bachelor | 1 | 6% |
Other | 2 | 12% |
Unknown | 6 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 24% |
Biochemistry, Genetics and Molecular Biology | 3 | 18% |
Economics, Econometrics and Finance | 2 | 12% |
Nursing and Health Professions | 1 | 6% |
Computer Science | 1 | 6% |
Other | 0 | 0% |
Unknown | 6 | 35% |