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Bifidobacteria modulate cognitive processes in an anxious mouse strain

Overview of attention for article published in Behavioural Brain Research, March 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#48 of 4,974)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

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Title
Bifidobacteria modulate cognitive processes in an anxious mouse strain
Published in
Behavioural Brain Research, March 2015
DOI 10.1016/j.bbr.2015.02.044
Pubmed ID
Authors

H.M. Savignac, M. Tramullas, B. Kiely, T.G. Dinan, J.F. Cryan

Abstract

Increasing evidence suggests that a brain-gut-microbiome axis exists, which has the potential to play a major role in modulating behaviour. However, the role of this axis in cognition remains relatively unexplored. Probiotics, which are commensal bacteria offering potential health benefit, have been shown to decrease anxiety, depression and visceral pain-related behaviours. In this study, we investigate the potential of two Bifidobacteria to modulate cognitive processes and visceral pain sensitivity. Adult male BALB/c mice were fed daily for 11 weeks with B. longum 1714, B. breve 1205 or vehicle treatment. Starting at week 4, animals were behaviourally assessed in a battery of tests relevant to different aspects of cognition, as well as locomotor activity and visceral pain. In the object recognition test, B. longum 1714-fed mice discriminated between the two objects faster than all other groups and B. breve 1205-fed mice discriminated faster than vehicle animals. In the Barnes maze, B. longum 1714-treated mice made fewer errors than other groups, suggesting a better learning. In the fear conditioning, B. longum 1714-treated group also showed better learning and memory, yet presenting the same extinction learning profile as controls. None of the treatments affected visceral sensitivity. Altogether, these data suggest that B. longum 1714 had a positive impact on cognition and also that the effects of individual Bifidobacteria strains do not generalise across the species. Clinical validation of the effects of probiotics on cognition is now warranted.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 474 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Portugal 1 <1%
United Kingdom 1 <1%
Italy 1 <1%
Greece 1 <1%
Spain 1 <1%
Unknown 466 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 68 14%
Student > Master 57 12%
Researcher 55 12%
Student > Ph. D. Student 54 11%
Student > Doctoral Student 26 5%
Other 79 17%
Unknown 135 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 78 16%
Medicine and Dentistry 64 14%
Neuroscience 44 9%
Biochemistry, Genetics and Molecular Biology 42 9%
Psychology 32 7%
Other 64 14%
Unknown 150 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 101. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2023.
All research outputs
#419,539
of 25,371,288 outputs
Outputs from Behavioural Brain Research
#48
of 4,974 outputs
Outputs of similar age
#5,103
of 291,952 outputs
Outputs of similar age from Behavioural Brain Research
#2
of 102 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,974 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,952 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.