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Novel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania infantum Infected Mice

Overview of attention for article published in ACS Medicinal Chemistry Letters, May 2018
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1 tweeter

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Title
Novel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania infantum Infected Mice
Published in
ACS Medicinal Chemistry Letters, May 2018
DOI 10.1021/acsmedchemlett.8b00053
Pubmed ID
Authors

Jelena Konstantinović, Milica Videnović, Stefania Orsini, Katarina Bogojević, Sarah D’Alessandro, Diletta Scaccabarozzi, Nataša Terzić Jovanović, Luigi Gradoni, Nicoletta Basilico, Bogdan A. Šolaja

Abstract

In this Letter, a detailed analysis of 30 4-aminoquinoline-based compounds with regard to their potential as antileishmanial drugs has been carried out. Ten compounds demonstrated IC50 < 1 μM against promastigote stages of L. infantum and L. tropica, and five compounds showed IC50 < 1 μM against intramacrophage L. infantum amastigotes. Two compounds showed dose-dependent enhancement of NO and ROS production by bone marrow-derived macrophages and remarkable reduction of parasite load in vivo, with advantage of being short-term and orally active. To the best of our knowledge, this is the first example of 4-amino-7-chloroquinoline derivatives active in Leishmania infantum infected mice.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 17%
Researcher 4 17%
Student > Bachelor 3 13%
Student > Master 3 13%
Other 2 8%
Other 3 13%
Unknown 5 21%
Readers by discipline Count As %
Chemistry 10 42%
Immunology and Microbiology 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Agricultural and Biological Sciences 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 4 17%
Unknown 4 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2018.
All research outputs
#10,670,281
of 13,415,438 outputs
Outputs from ACS Medicinal Chemistry Letters
#957
of 1,188 outputs
Outputs of similar age
#202,205
of 269,813 outputs
Outputs of similar age from ACS Medicinal Chemistry Letters
#22
of 31 outputs
Altmetric has tracked 13,415,438 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,188 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,813 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.