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Interrelations between Essential Metal Ions and Human Diseases

Overview of attention for book
Attention for Chapter 15: Arsenic. Can This Toxic Metalloid Sustain Life?
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About this Attention Score

  • Among the highest-scoring outputs from this source (#32 of 134)
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 X user
wikipedia
5 Wikipedia pages

Citations

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193 Dimensions

Readers on

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19 Mendeley
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Chapter title
Arsenic. Can This Toxic Metalloid Sustain Life?
Chapter number 15
Book title
Interrelations between Essential Metal Ions and Human Diseases
Published in
Metal ions in life sciences, November 2013
DOI 10.1007/978-94-007-7500-8_15
Pubmed ID
Book ISBNs
978-9-40-077499-5, 978-9-40-077500-8
Authors

Dean E. Wilcox

Editors

Astrid Sigel, Helmut Sigel, Roland K.O. Sigel

Abstract

It was recently reported that a bacterium, Halomonas species GFAJ-1, isolated from arsenic-rich Mono Lake and further selected for growth under conditions of high arsenate and low phosphate, is able to grow using arsenic instead of phosphorus. This claim, and subsequent studies to evaluate GFAJ-1, has brought new attention to the question of whether arsenic can play an essential or sustaining role for living organisms. If true, this would be in stark contrast to the well known toxicity of this element and its ability to cause a number of diseases, including cancer of the skin, lung, bladder, liver, and kidney. However, while deadly at high doses, arsenic oxide is also an approved and effective chemotherapeutic drug for the treatment of acute promyelocytic leukemia (APL). This review examines the evidence that arsenic may be a beneficial nutrient at trace levels below the background to which living organisms are normally exposed. It also examines whether arsenic can be used to sustain organisms growing under high arsenic conditions, specifically the results from recent studies of arsenic biochemistry motivated by the report of GFAJ-1. Both of these topics are considered in the context of the toxicity of this element and its ability to cause cancer and other diseases, yet its Janus-faced ability to effectively treat APL.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 21%
Researcher 4 21%
Student > Bachelor 2 11%
Student > Ph. D. Student 2 11%
Other 1 5%
Other 2 11%
Unknown 4 21%
Readers by discipline Count As %
Medicine and Dentistry 5 26%
Agricultural and Biological Sciences 2 11%
Business, Management and Accounting 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 4 21%
Unknown 5 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2018.
All research outputs
#6,941,088
of 22,758,963 outputs
Outputs from Metal ions in life sciences
#32
of 134 outputs
Outputs of similar age
#82,043
of 302,273 outputs
Outputs of similar age from Metal ions in life sciences
#9
of 19 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 134 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,273 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.