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Interrelations between Essential Metal Ions and Human Diseases

Overview of attention for book
Attention for Chapter 12: Zinc and Human Disease
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#21 of 135)
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

1 policy source
9 Wikipedia pages


193 Dimensions

Readers on

75 Mendeley
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Chapter title
Zinc and Human Disease
Chapter number 12
Book title
Interrelations between Essential Metal Ions and Human Diseases
Published in
Metal ions in life sciences, November 2013
DOI 10.1007/978-94-007-7500-8_12
Pubmed ID
Book ISBNs
978-9-40-077499-5, 978-9-40-077500-8

Wolfgang Maret, Maret, Wolfgang


Astrid Sigel, Helmut Sigel, Roland K.O. Sigel


The vast knowledge of the physiologic functions of zinc in at least 3000 proteins and the recent recognition of fundamental regulatory functions of zinc(II) ions released from cells or within cells links this nutritionally essential metal ion to numerous diseases. However, this knowledge so far has had remarkably limited impact on diagnosing, preventing, and treating human diseases. One major roadblock is a lack of suitable biomarkers that would detect changes in cellular zinc metabolism and relate them to specific disease outcomes. It is not only the right amount of zinc in the diet that maintains health. At least as important is the proper functioning of the dozens of proteins that control cellular zinc homeostasis, regulate intracellular traffic of zinc between the cytosol and vesicles/organelles, and determine the fluctuations of signaling zinc(II) ions. Cellular zinc deficiencies or overloads, a term referring to zinc concentrations exceeding the cellular zinc buffering capacity, compromise the redox balance. Zinc supplementation may not readily remedy zinc deficiency if other factors limit the capability of a cell to control zinc. The role of zinc in human diseases requires a general understanding of the wide spectrum of functions of zinc, how zinc is controlled, how it interacts with the metabolism of other metal ions, in particular copper and iron, and how perturbation of specific zinc-dependent molecular processes causes disease and influences the progression of disease.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 1%
United Kingdom 1 1%
Unknown 73 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 17%
Researcher 11 15%
Student > Ph. D. Student 9 12%
Student > Doctoral Student 6 8%
Student > Bachelor 5 7%
Other 9 12%
Unknown 22 29%
Readers by discipline Count As %
Medicine and Dentistry 14 19%
Biochemistry, Genetics and Molecular Biology 7 9%
Agricultural and Biological Sciences 5 7%
Chemistry 5 7%
Earth and Planetary Sciences 4 5%
Other 15 20%
Unknown 25 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2023.
All research outputs
of 23,394,907 outputs
Outputs from Metal ions in life sciences
of 135 outputs
Outputs of similar age
of 305,590 outputs
Outputs of similar age from Metal ions in life sciences
of 19 outputs
Altmetric has tracked 23,394,907 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 135 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,590 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.