Chapter title |
Cobalt and corrinoid transport and biochemistry.
|
---|---|
Chapter number | 10 |
Book title |
Metallomics and the Cell
|
Published in |
Metal ions in life sciences, December 2012
|
DOI | 10.1007/978-94-007-5561-1_10 |
Pubmed ID | |
Book ISBNs |
978-9-40-075560-4, 978-9-40-075561-1
|
Authors |
Valentin Cracan, Ruma Banerjee, Cracan, Valentin, Banerjee, Ruma |
Editors |
Lucia Banci |
Abstract |
In this chapter, we focus on the biochemistry of non-corrin cobalt and on a subset of corrinoid-containing enzymes. We review the import of cobalt in prokaryotes and discuss two members of the non-corrin cobalt-dependent enzymes, nitrile hydratase and methionine aminopeptidase. Cobalt is best known for its central role in alkylcorrinoid cofactors, where the unique properties of the cobalt-carbon bond are exploited to catalyze chemically challenging biotransformations. We discuss the import of corrinoids and the reactions catalyzed by the acyl-CoA mutases, the -fastest-growing subfamily of adenosylcobalamin (AdoCbl)-dependent enzymes. AdoCbl is used as a radical reservoir to catalyze 1,2 rearrangement reactions. The loading of AdoCbl-dependent enzymes with the correct cofactor form is critically important for their functions and is gated by chaperones that use the chemical energy of GTP hydrolysis to ensure the fidelity of the process. Recent insights into the organization and editing functions of G-protein chaperones in the context of AdoCbl-dependent enzymes that they support, are discussed. |
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United Kingdom | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 16 | 100% |
Demographic breakdown
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Professor > Associate Professor | 3 | 19% |
Student > Ph. D. Student | 3 | 19% |
Professor | 2 | 13% |
Researcher | 1 | 6% |
Student > Master | 1 | 6% |
Other | 0 | 0% |
Unknown | 6 | 38% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 2 | 13% |
Chemistry | 2 | 13% |
Physics and Astronomy | 1 | 6% |
Environmental Science | 1 | 6% |
Other | 2 | 13% |
Unknown | 6 | 38% |