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Kinetochore-localized PP1–Sds22 couples chromosome segregation to polar relaxation

Overview of attention for article published in Nature, July 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

16 news outlets
3 blogs
42 tweeters
14 Facebook pages
1 Google+ user


63 Dimensions

Readers on

155 Mendeley
1 CiteULike
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Kinetochore-localized PP1–Sds22 couples chromosome segregation to polar relaxation
Published in
Nature, July 2015
DOI 10.1038/nature14496
Pubmed ID

Nelio T. L. Rodrigues, Sergey Lekomtsev, Silvana Jananji, Janos Kriston-Vizi, Gilles R. X. Hickson, Buzz Baum


Cell division requires the precise coordination of chromosome segregation and cytokinesis. This coordination is achieved by the recruitment of an actomyosin regulator, Ect2, to overlapping microtubules at the centre of the elongating anaphase spindle. Ect2 then signals to the overlying cortex to promote the assembly and constriction of an actomyosin ring between segregating chromosomes. Here, by studying division in proliferating Drosophila and human cells, we demonstrate the existence of a second, parallel signalling pathway, which triggers the relaxation of the polar cell cortex at mid anaphase. This is independent of furrow formation, centrosomes and microtubules and, instead, depends on PP1 phosphatase and its regulatory subunit Sds22 (refs 2, 3). As separating chromosomes move towards the polar cortex at mid anaphase, kinetochore-localized PP1-Sds22 helps to break cortical symmetry by inducing the dephosphorylation and inactivation of ezrin/radixin/moesin proteins at cell poles. This promotes local softening of the cortex, facilitating anaphase elongation and orderly cell division. In summary, this identifies a conserved kinetochore-based phosphatase signal and substrate, which function together to link anaphase chromosome movements to cortical polarization, thereby coupling chromosome segregation to cell division.

Twitter Demographics

The data shown below were collected from the profiles of 42 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
United Kingdom 1 <1%
Mexico 1 <1%
Spain 1 <1%
Japan 1 <1%
Unknown 150 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 26%
Researcher 37 24%
Student > Master 18 12%
Student > Bachelor 11 7%
Professor 8 5%
Other 23 15%
Unknown 17 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 67 43%
Biochemistry, Genetics and Molecular Biology 50 32%
Physics and Astronomy 5 3%
Neuroscience 4 3%
Engineering 2 1%
Other 5 3%
Unknown 22 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 168. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2016.
All research outputs
of 16,150,423 outputs
Outputs from Nature
of 76,506 outputs
Outputs of similar age
of 233,092 outputs
Outputs of similar age from Nature
of 940 outputs
Altmetric has tracked 16,150,423 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 76,506 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 87.2. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,092 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 940 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.