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Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, June 2018
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Title
Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe
Published in
Revista da Sociedade Brasileira de Medicina Tropical, June 2018
DOI 10.1590/0037-8682-0024-2018
Pubmed ID
Authors

Fábia Regina dos Santos, Diana Matos Euzébio, Genilde Gomes de Oliveira, Mayra Souza Chagas, Alex Ricardo Ferreira, Lídia Almeida Mendonça, Dalmo Correia, Angela Maria da Silva

Abstract

Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, being one of the leading causes of morbidity and mortality in the Americas with an estimated six to seven million infected people worldwide. In Brazil, the improvement in vector control and blood donor screening has evidenced the important epidemiological role of congenital transmission of Chagas disease. A serological survey for Chagas disease was performed in 3,952 newborns in the southern region of Sergipe using paper filter disks of dried blood samples. The newborns were screened using the Sergipe State Neonatal Screening Program between July 2015 and July 2016, and 3,749 and 750 blood samples were obtained for the IgG enzyme-linked immunosorbent assay and indirect immunofluorescence assay, respectively. In addition, mothers of the children who presented initial reagent serology were examined. Among 3,749 blood samples, samples of two children were positive for the enzyme-linked immunosorbent assay; however, their confirmation test results were negative, suggesting passive transfer of the mother's antibody. One puerpera was identified with Chagas disease, with a prevalence of 0.02%. Congenital Chagas disease was not observed in newborns in the Southern region of Sergipe. However, Chagas disease was observed in women of reproductive age. Therefore, effective measurements for monitoring and systematic evaluation should be conducted. The Neonatal Screening Program proved to be an effective public health strategy for the prevention and control of Chagas disease.

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The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 13%
Student > Bachelor 6 11%
Student > Ph. D. Student 5 9%
Researcher 4 7%
Other 4 7%
Other 10 19%
Unknown 18 33%
Readers by discipline Count As %
Medicine and Dentistry 6 11%
Immunology and Microbiology 4 7%
Agricultural and Biological Sciences 4 7%
Biochemistry, Genetics and Molecular Biology 3 6%
Engineering 3 6%
Other 10 19%
Unknown 24 44%