| Chapter title |
Developmental Origins of Nonalcoholic Fatty Liver Disease (NAFLD)
|
|---|---|
| Chapter number | 4 |
| Book title |
Developmental Origins of Health and Disease (DOHaD)
|
| Published in |
Advances in experimental medicine and biology, January 2018
|
| DOI | 10.1007/978-981-10-5526-3_4 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-105525-6, 978-9-81-105526-3
|
| Authors |
Hiroaki Itoh, Naohiro Kanayama, Itoh, Hiroaki, Kanayama, Naohiro |
| Abstract |
Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Its prevalence is currently increasing not only in developed obese countries but also in developing countries. Recent findings from human cohorts and animal studies suggest that a nutritional imbalance in the early critical period is causatively associated with the incidence of NAFLD in later life. Based on the current theory of the developmental origins of health and disease (DOHaD), undernourishment and overnourishment in utero are both hypothesized to prime the predisposition for hepatic fat storage. Current knowledge on the developmental origins of NAFLD is introduced in this chapter. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 18% |
| Student > Master | 5 | 15% |
| Student > Ph. D. Student | 5 | 15% |
| Other | 2 | 6% |
| Professor > Associate Professor | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 10 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 33% |
| Agricultural and Biological Sciences | 4 | 12% |
| Social Sciences | 2 | 6% |
| Sports and Recreations | 1 | 3% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 12 | 36% |